ArticleHypertension (Dallas, Tex. : 1979)2014
Local effects of pregnancy on connexin proteins that mediate Ca2+-associated uterine endothelial NO synthesis.
Article in Hypertension (Dallas, Tex. : 1979), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Cytokine concentrations direct endothelial function in pregnancy and preeclampsia.The Journal of endocrinology · 2021Article
- Influence of Estrogens on Uterine Vascular Adaptation in Normal and Preeclamptic Pregnancies.International journal of molecular sciences · 2020Review
- Plasticity of the Maternal Vasculature During Pregnancy.Annual review of physiology · 2019Review
- Venoarterial communication mediates arterial wall shear stress-induced maternal uterine vascular remodeling during pregnancy.American journal of physiology. Heart and circulatory physiology · 2018Article
- Pregnancy-adapted uterine artery endothelial cell Ca2+ signaling and its relationship with membrane potential.Physiological reports · 2017Article
- Altered Endothelial Nitric Oxide Signaling as a Paradigm for Maternal Vascular Maladaptation in Preeclampsia.Current hypertension reports · 2017Review
- Cyclic Nucleotides Differentially Regulate Cx43 Gap Junction Function in Uterine Artery Endothelial Cells From Pregnant Ewes.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Uterine artery leptin receptors during the ovarian cycle and pregnancy regulate angiogenesis in ovine uterine artery endothelial cells†.Biology of reproduction · 2017Article
- Positive versus negative effects of VEGF165 on Ca2+ signaling and NO production in human endothelial cells.American journal of physiology. Heart and circulatory physiology · 2017Article
- Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia.The Journal of endocrinology · 2017Review
- Domain-Specific Partitioning of Uterine Artery Endothelial Connexin43 and Caveolin-1.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells.Molecular and cellular endocrinology · 2015Article
- Gap junction regulation of vascular tone: implications of modulatory intercellular communication during gestation.Advances in experimental medicine and biology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledUterine artery adaptations during gestation facilitate increases in uterine blood flow and fetal growth. HYPOTHESIS: local expression and distribution of uterine artery connexins play roles in mediating in vivo gestational eNOS activation and NO production. We established an ovine model restricting pregnancy to a single uterine horn and measured uterine blood flow, uterine artery shear stress, connexins 37/43, and P(635)eNOS protein levels in uterine artery and systemic artery (omental and renal) endothelium and connexins in vascular smooth muscle. Uterine blood flow and shear stress were locally (unilaterally) and substantially elevated by gestation. During pregnancy, uterine artery endothelial gap junction proteins connexins 37/43 were locally regulated in the gravid horn and elevated 10.3- and 25.6-fold; uterine artery endothelial P(635)eNOS and total eNOS were elevated 3.3- and 2.9-fold; whereas uterine artery vascular smooth muscle connexins 37/43 were locally elevated 12.5- and 5.9-fold, respectively. Less pronounced changes were observed in systemic vasculature except for significant pregnancy-associated increases in omental artery vascular smooth muscle connexin 43 and omental artery endothelial P(635)eNOS and total eNOS. Gap junction blockade using connexin 43, but not connexin 37-specific Gap peptides, abrogated uterine artery endothelial ATP-induced Ca(2+)-mediated NO production. Thus, uterine artery endothelial connexin 43, but not connexin 37, regulates Ca(2+)-mediated NO production required for the vasodilation to accommodate increases in uterine blood flow and shear stress during healthy pregnancies.
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