Trial reportJournal of hypertension2014
The effects of weight loss and salt reduction on visit-to-visit blood pressure variability: results from a multicenter randomized controlled trial.
Trial report in Journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Long-term effects of weight-reducing diets in people with hypertension.The Cochrane database of systematic reviews · 2021Pooled it
- Long-term effects of weight-reducing diets in people with hypertension.The Cochrane database of systematic reviews · 2016Pooled it
- The science of salt: a systematic review of clinical salt studies 2013 to 2014.Journal of clinical hypertension (Greenwich, Conn.) · 2015Pooled it
- Reducing blood pressure variability-results from a single-arm proof of concept prospective trial.Scientific reports · 2025Trial
- Effect of Intensive Lifestyle Intervention on Cardiovascular Risk Factors: Analysis From the Perspective of Long-Term Variability.Journal of the American Heart Association · 2024Trial
- Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population.Journal of the American Heart Association · 2023Trial
- The Impact of a Western Diet with High Salt on Metabolic Outcomes in Male C57bl/6J Mice.The journal of nutritional physiology · 2026Article
- Urinary chloride-to-potassium ratio as a potential novel index for MR activity in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Dietary Reference Intakes of sodium for Koreans: focusing on a new DRI component for chronic disease risk reduction.Nutrition research and practice · 2022Review
- Non-interventional weight changes affect systolic blood pressure in normotensive individuals.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Blood Pressure Variability and Therapeutic Implications in Hypertension and Cardiovascular Diseases.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
- Finding a Signal in the Noise.Clinical journal of the American Society of Nephrology : CJASN · 2016Article
- Effect of One-Week Salt Restriction on Blood Pressure Variability in Hypertensive Patients with Type 2 Diabetes.PloS one · 2016Article
- Visit-to-Visit Variability of Systolic Blood Pressure and Cardiovascular Disease.Current hypertension reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesAs evidence suggests visit-to-visit variability (VVV) of blood pressure (BP) is associated with cardiovascular events and mortality, there is increasing interest in identifying interventions that reduce VVV of BP. We investigated the effects of weight loss and sodium reduction, alone or in combination, on VVV of BP in participants enrolled in phase II of the Trials of Hypertension Prevention.
methodsBP readings were taken at 6-month intervals for 36 months in 1820 participants with high-normal DBP who were randomized to weight loss, sodium reduction, combination (weight loss and sodium reduction), or usual care groups. VVV of BP was defined as the SD of BP across six follow-up visits.
resultsVVV of SBP was not significantly different between participants randomized to the weight loss (7.2 ± 3.1 mmHg), sodium reduction (7.1 ± 3.0 mmHg), or combined (6.9 ± 2.9 mmHg) intervention groups vs. the usual care group (6.9 ± 2.9 mmHg). In a fully adjusted model, no difference (0.0 ± 0.2 mmHg) in VVV of SBP was present between individuals who successfully maintained their weight loss vs. individuals who did not lose weight during follow-up (P = 0.93). Also, those who maintained a reduced sodium intake throughout follow-up did not have lower VVV of SBP compared to those who did not reduce their sodium intake (0.1 ± 0.3 mmHg; P = 0.77). Results were similar for VVV of DBP.
conclusionsThese findings suggest that weight loss and sodium reduction may not be effective interventions for lowering VVV of BP in individuals with high-normal DBP.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.