Evidence for separate inheritance of mania and depression challenges current concepts of bipolar mood disorder.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. The effect of sleep-wake behaviors on the onset of mania in youth: A computational model.European psychiatry : the journal of the Association of European Psychiatrists · 2026
   Article
2. A Critical Overview of the Validity of the Current Concept of Bipolar Disorder.Journal of personalized medicine · 2025
   Review
3. Does circadian dysrhythmia drive the switch into high- or low-activation states in bipolar I disorder?Bipolar disorders · 2023
   Review
4. The structure of mania: An overview of factorial analysis studies.European psychiatry : the journal of the Association of European Psychiatrists · 2020
   Review
5. Clinical Stage Transitions in Persons Aged 12 to 25 Years Presenting to Early Intervention Mental Health Services With Anxiety, Mood, and Psychotic Disorders.JAMA psychiatry · 2019
   Article
6. Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder.Translational psychiatry · 2018
   Article
7. Historical Underpinnings of Bipolar Disorder Diagnostic Criteria.Behavioral sciences (Basel, Switzerland) · 2016
   Review
8. Familiality of Psychotic Disorders: A Polynosologic Study in Multiplex Families.Schizophrenia bulletin · 2016
   Article
9. Unipolar mania: a necessary diagnostic concept.European archives of psychiatry and clinical neuroscience · 2015
   Review
10. Influencing circadian and sleep-wake regulation for prevention and intervention in mood and anxiety disorders: what makes a good homeostat?Annals of the New York Academy of Sciences · 2014
    Article

Corrections and comments

• Comment on
  Specificity of psychosis, mania and major depression in a contemporary family study.2014
• Comment on
  Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders.2014

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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