ArticleCritical care medicine2014
Immunological characterization of compensatory anti-inflammatory response syndrome in patients with severe sepsis: a longitudinal study*.
Article in Critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 78 citations in OpenAlex.
- Illustrating the functional heterogeneity of M-MDSCs to predict sepsis outcomes.Journal of advanced research · 2026Article
- Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.American journal of respiratory and critical care medicine · 2025Observational
- Association between intracellular adenosine triphosphate content of CD4Immunity, inflammation and disease · 2024Observational
- Diagnostic and prognostic significance of apelin-13, APJ for sepsis in the emergency department: A prospective study.Heliyon · 2024Article
- The correlation between serum calcium levels and prognosis in patients with severe acute osteomyelitis.Frontiers in immunology · 2024Article
- During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant.Clinical reviews in allergy & immunology · 2023Review
- Review
- Dynamic changes in human single-cell transcriptional signatures during fatal sepsis.Journal of leukocyte biology · 2021Article
- Prognosis-related classification and dynamic monitoring of immune status in patients with sepsis: A prospective observational study.World journal of emergency medicine · 2021Article
- The unleashing of the immune system in COVID-19 and sepsis: the calm before the storm?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections.Frontiers in endocrinology · 2020Review
- IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial.Annals of intensive care · 2019Article
- A Comparative Review of Equine SIRS, Sepsis, and Neutrophils.Frontiers in veterinary science · 2019Review
- Immune therapy in sepsis: Are we ready to try again?Journal of the Intensive Care Society · 2018Review
- Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality.Critical care (London, England) · 2018Article
- Pyruvate enhancement of cardiac performance: Cellular mechanisms and clinical application.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Interleukin-6 is a key factor for immunoglobulin-like transcript-4-mediated immune injury in sepsis.Journal of intensive care · 2018Article
- Sepsis and Nosocomial Infection: Patient Characteristics, Mechanisms, and Modulation.Frontiers in immunology · 2018Review
- Article
- Dynamics of monocytic HLA-DR expression differs between bacterial etiologies during the course of bloodstream infection.PloS one · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo perform a complete immunological characterization of compensatory anti-inflammatory response syndrome in patients with sepsis and to explore the relationship between these changes and clinical outcomes of 28-day mortality and secondary infections.
designProspective single-center study conducted between April 2011 and December 2012.
settingICUs from Hospital Universitario San Vicente Fundación at Medellin, Colombia. PATIENTS: One hundred forty-eight patients with severe sepsis.
interventionsNone. MEASUREMENTS AND MAIN
resultsAt days 0, 1, 3, 5, 10, and 28, we determined the expression of HLA-DR in monocytes and the apoptosis and the proliferation index in T lymphocytes, as well as the levels of tumor necrosis factor-α, interleukin-6, interleukin-1β, interleukin-10, and transforming growth factor-β in both plasma and cell culture supernatants of peripheral blood mononuclear cells. The mean percentage of HLA-DR was 60.7 at enrollment and increased by 0.9% (95% CI, 0.7-1.2%) per day. The mean percentage of CD4 T cells and CD8 T cells AV+/7-AAD- at enrollment was 37.2% and 20.4%, respectively, but it diminished at a rate of -0.5% (95% CI, -0.7% to -0.3%) and -0.3% (95% CI, -0.4% to -0.2%) per day, respectively. Plasma levels of interleukin-6 and interleukin-10 were 290 and 166 pg/mL and decreased at a rate of -7.8 pg/mL (95% CI, -9.5 to -6.1 pg/mL) and -4 pg/mL (95% CI, -5.1 to -2.8 pg/mL) per day, respectively. After controlling for confounders, only sustained plasma levels of interleukin-6 increase the risk of death (hazard ratio 1.003; 95% CI, 1.001-1.006).
conclusionsWe found no evidence to support a two-phase model of sepsis pathophysiology. However, immunological variables did behave in a mixed and time-dependent manner. Further studies should evaluate changes over time of interleukin-6 plasma levels as a prognostic biomarker for critically ill patients.
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