Evidence map›Paper›PMID 24365855›Full record

ArticleCancer biology & therapy2014

Bidirectional conversion of intestinal epithelial cells: NFκB is key.

Amelie Boquoi

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer biology & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Amelie BoquoiDepartment of Hematology, Oncology, and Clinical Immunology; Heinrich-Heine-University Duesseldorf; Duesseldorf, Germany.
Hochschule Düsseldorf University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NFκB represents a key transcription factor within the inflammatory tumor microenvironment; however, NFκB's function in tumor-initiating cells has not been examined yet. A recent Cell paper by Schwitalla et al. reports that NFκB modulates Wnt signaling and shows that enhanced Wnt activation induces dedifferentiation of nonstem cells that acquire tumor-initiating capacity.

Indexed as

Cell DedifferentiationCell Transformation, NeoplasticAnimalsColonic NeoplasmsFemaleHumansMaleNeoplastic Stem Cellschronic inflammationdedifferentiationEMTLgr5microenvironmentNFκBWnt signaling

Identifiers

PMID24365855
PMCPMC3928131
OpenAlexW2313260012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.