Evidence map›Paper›PMID 24365785›Full record

ArticleThe pharmacogenomics journal2014

Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes.

J Graessler, T D Bornstein, D Goel, V P Bhalla, T Lohmann, T Wolf, M Koch, Y Qin, J Licinio, M-L Wong and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Potential Application ofScientific reports · 2017
    Article
  17. Article
  18. Article
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 6 countries.

J GraesslerDepartment of Medicine III, Carl Gustav Carus Medical School, TU Dresden, Dresden, Germany.
T D BornsteinDepartment of Medicine III, Carl Gustav Carus Medical School, TU Dresden, Dresden, Germany.
D GoelDepartment of Minimal Access, Bariatric and Surgical Gastroenterology, BLK Super Speciality Hospital, New Delhi, India.
V P BhallaDepartment of Minimal Access, Bariatric and Surgical Gastroenterology, BLK Super Speciality Hospital, New Delhi, India.
T LohmannDepartment of Internal Medicine, Dresden Interdisciplinary Adiposity Center, Community Hospital Dresden-Neustadt, Dresden, Germany.
T WolfDepartment of Internal Medicine, Dresden Interdisciplinary Adiposity Center, Community Hospital Dresden-Neustadt, Dresden, Germany.
M KochDepartment for Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus Medical School, TU Dresden, Dresden, Germany.
Y QinResearch & Cooperation Division, BGI-Shenzhen, Main Building Floor 2, Beishan Industrial Zone, Shenzhen, China.
J LicinioDepartment of Translational Medicine, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
M-L WongDepartment of Translational Medicine, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
T ChavakisDepartment of Medicine III, Carl Gustav Carus Medical School, TU Dresden, Dresden, Germany.
A XuDepartment of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
A ShevchenkoMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
K Schuhmann1] Department of Medicine III, Carl Gustav Carus Medical School, TU Dresden, Dresden, Germany [2] Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
P E H SchwarzDepartment of Medicine III, Carl Gustav Carus Medical School, TU Dresden, Dresden, Germany.
K-M SchulteDepartment of Surgery, King's College Hospital, NHS Foundation Trust, London, UK.
A PatelDepartment of Surgery, King's College Hospital, NHS Foundation Trust, London, UK.
S R Bornstein1] Department of Medicine III, Carl Gustav Carus Medical School, TU Dresden, Dresden, Germany [2] Department of Endocrinology and Diabetes, King's College, London, UK.
TU Dresden · DEAustralian National University · AUBLK Super Speciality Hospital · INKing's College Hospital NHS Foundation Trust · GBMax Planck Institute of Molecular Cell Biology and Genetics · DEStädtisches Klinikum Dresden · DEBGI Group (China) · CNChinese University of Hong Kong · CNKing's College London · GBUniversity Hospital Carl Gustav Carus · DE

Funding

Clinical Neuroendocrinology of LeptinK24RR016996 · NCRR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LICINIO, JULIO · 2002 to 2006
$662k
NCRR NIH HHS K24 RR016996
6 · The paper itself

Abstract

Bariatric surgery is a well-established approach to improve metabolic disease in morbidly obese patients with high cardiovascular risk. The post-operative normalization of lipid metabolism has a central role in the prevention of future cardiovascular events. The aim of the present study therefore was to characterize changes of plasma lipidomic patterns, consisting of 229 lipid species of 13 lipid classes, 3 months after Roux-en-Y gastric bypass (RYGB) in morbidly obese patients with and without diabetes. RYGB resulted in a 15-32% decrease of body mass index, which was associated with a significant reduction of total cholesterol (TC, -28.3%; P=0.02), LDL-cholesterol (LDL-C, -26.8%; P=0.03) and triglycerides (TGs, -63.0%; P=0.05) measured by routine clinical chemistry. HDL-cholesterol remained unchanged. The effect of RYGB on the plasma lipidomic profile was characterized by significant decreases of 87 lipid species from triacylglycerides (TAGs), cholesterol esters (CholEs), lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), phosphatidylethanolamine ethers (PEOs), phosphatidylinositols (PIs) and ceramides (Cers). The total of plasma lipid components exhibited a substantial decline of 32.6% and 66 lipid species showed a decrease by over 50%. A direct correlation with HbA1C values could be demonstrated for 24 individual lipid species (10 TAG, three CholE, two LPC, one lysophosphatidylcholine ethers (LPCO) (LPC ether), one PC, two phosphatidylcholine ethers (PCO) and five Cer). Notably, two lipid species (TAG 58:5 and PEO 40:5) were inversely correlated with HbA1C. LPCO, as single whole lipid class, was directly related to HbA1C. These data indicate that RYGB-induced modulation of lipidomic profiles provides important information about post-operative metabolic adaptations and might substantially contribute to improvements of glycemic control. These striking changes in the human plasma lipidome may explain acute, weight independent and long-term effects of RYGB on the cardiovascular system, mental status and immune regulation.

Indexed as

Gastric BypassChromatography, High Pressure LiquidDiabetes Mellitus, Type 2HumansLipidsObesity, MorbidLipids

Identifiers

PMID24365785
OpenAlexW2002567960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.