Evidence map›Paper›PMID 24365704›Full record

ReviewActa biomaterialia2014

Designing ECM-mimetic materials using protein engineering.

Lei Cai, Sarah C Heilshorn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Targeted Drug Delivery via the Use of ECM-Mimetic Materials.Frontiers in bioengineering and biotechnology · 2020
    Review
  16. Molecular Regulators of Cellular Mechanoadaptation at Cell-Material Interfaces.Frontiers in bioengineering and biotechnology · 2020
    Review
  17. Article
  18. Review
  19. Review
  20. Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lei CaiDepartment of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA.
Sarah C HeilshornDepartment of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA. Electronic address: heilshorn@stanford.edu.

Funding

Three-dimensional Scaffold-based Systems for Primary Human Intestinal CultureR01DK085720 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2009 to 2013
$3.7M
Engineering 3D in vitro niches to reveal fundamentals of cellular biomechanicsDP2OD006477 · OD · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C · 2009 to 2009
$2.4M
3D Bioengineering Strategies to Mimic Human Skeletal Muscle Progenitor Cell NicheR21AR062359 · NIAMS · STANFORD UNIVERSITY · PI BLAU, HELEN M, HEILSHORN, SARAH C · 2011 to 2012
$367k
NIAMS NIH HHS R21 AR062359NIAMS NIH HHS R21-AR062359NIDDK NIH HHS R01 DK085720NIDDK NIH HHS R01-DK085720NIH HHS DP2 OD006477NIH HHS DP2-OD006477
6 · The paper itself

Abstract

The natural extracellular matrix (ECM), with its multitude of evolved cell-instructive and cell-responsive properties, provides inspiration and guidelines for the design of engineered biomaterials. One strategy to create ECM-mimetic materials is the modular design of protein-based engineered ECM (eECM) scaffolds. This modular design strategy involves combining multiple protein domains with different functionalities into a single, modular polymer sequence, resulting in a multifunctional matrix with independent tunability of the individual domain functions. These eECMs often enable decoupled control over multiple material properties for fundamental studies of cell-matrix interactions. In addition, since the eECMs are frequently composed entirely of bioresorbable amino acids, these matrices have immense clinical potential for a variety of regenerative medicine applications. This brief review demonstrates how fundamental knowledge gained from structure-function studies of native proteins can be exploited in the design of novel protein-engineered biomaterials. While the field of protein-engineered biomaterials has existed for over 20years, the community is only now beginning to fully explore the diversity of functional peptide modules that can be incorporated into these materials. We have chosen to highlight recent examples that either (i) demonstrate exemplary use as matrices with cell-instructive and cell-responsive properties or (ii) demonstrate outstanding creativity in terms of novel molecular-level design and macro-level functionality.

Indexed as

Amino Acid SequenceAnimalsBiomimetic MaterialsExtracellular MatrixHumansMolecular Sequence DataPeptidesProtein EngineeringPeptidesExtracellular matrixProtein engineeringRecombinant protein synthesisThree-dimensional hydrogelsTissue engineering

Identifiers

PMID24365704
PMCPMC3973542

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.