ArticleJournal of pediatric psychology
Electronic monitoring of medication adherence in early maintenance phase treatment for pediatric leukemia and lymphoma: identifying patterns of nonadherence.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Journal of pediatric psychology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Adherence to Oral Chemotherapy in Acute Lymphoblastic Leukemia during Maintenance Therapy in Children, Adolescents, and Young Adults: A Systematic Review.Current oncology (Toronto, Ont.) · 2023Pooled it
- Patient-Tailored Interventions to Improve Specialty Medication Adherence: Results from a Prospective Randomized Controlled Trial.The American journal of medicine · 2023Trial
- Controller adherence following hospital discharge in high risk children: A pilot randomized trial of text message reminders.The Journal of asthma : official journal of the Association for the Care of Asthma · 2019Trial
- Trial
- Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation.Journal of pediatric psychology · 2017Trial
- Digital Health in Pediatric Oncology and Hematooncology: A Quasi-Systematic Review of Telehealth, mHealth and Precision Medicine.Cancer management and research · 2026Review
- Medication adherence among children with heart failure at the University of Gondar Comprehensive Specialized Hospital Gondar Northwest Ethiopia.Scientific reports · 2025Article
- DNA-incorporated thioguanine to detect potential non-adherence to maintenance therapy in acute lymphoblastic leukemia.Cancer chemotherapy and pharmacology · 2025Article
- Medication self-management behaviors of adolescents and young adults with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Pediatric Psychosocial Standards of Care in action: Research that bridges the gap from need to implementation.Psycho-oncology · 2020Article
- The Relationship between Health Disparities, Psychosocial Functioning and Health Outcomes in Pediatric Hematology-Oncology and Stem Cell Transplant Populations: Recommendations for Clinical Care.International journal of environmental research and public health · 2020Article
- When Multiple Objective Measures of Medication Adherence Indicate Incongruent Adherence Results: An Example with Pediatric Cancer.International journal of environmental research and public health · 2020Article
- Longitudinal Patterns of Social Problem-Solving Skills in an Ethnically Diverse Sample of Pediatric Patients with Cancer and their Caregivers.International journal of environmental research and public health · 2020Article
- Reducing Stroke Risk in Atrial Fibrillation: Adherence to Guidelines Has Improved, but Patient Persistence with Anticoagulant Therapy Remains Suboptimal.Korean circulation journal · 2019Review
- Automated Adherence Reminders for High Risk Children With Asthma: A Research Protocol.JMIR research protocols · 2017Article
- Electronic Adherence Monitoring in a High-Utilizing Pediatric Asthma Cohort: A Feasibility Study.JMIR research protocols · 2016Article
- Medication adherence decision-making among adolescents and young adults with cancer.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2016Article
- Teenagers and Young Adults with Cancer: An Exploration of Factors Contributing to Treatment Adherence.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesReview
- Adherence to Oral Medications During Maintenance Therapy Among Children and Adolescents With Acute Lymphoblastic Leukemia: A Medication Refill Analysis.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Jennifer M RohanDepartment of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA Department of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA rohanjenm@gmail.com.
Dennis DrotarDepartment of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA Department of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA.
Melissa AlderferDepartment of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA.
Crista Wetherington DonewarDepartment of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA.
Linda EwingDepartment of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA.
Ernest R KatzDepartment of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA.
Anna MurielDepartment of Psychology, University of Cincinnati, USA, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA, Department of Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital Cancer Center, USA.
Cincinnati Children's Hospital Medical Center · US
Funding
INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4MInstitutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9MPromoting Treatment Adherence in Adolescent LeukemiaR01CA119162 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI DROTAR, DENNIS D · 2007 to 2012
$3.3MThe Impact of Treatment Adherence on A Clinical Biomarker in Pediatric Acute LympF31CA168307 · NCI · UNIVERSITY OF CINCINNATI · PI ROHAN, JENNIFER MARIE · 2013 to 2014
$49kNCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1TR000003NCI NIH HHS 1F31CA168307NCI NIH HHS 1R01CA119162NCI NIH HHS F31 CA168307NCRR NIH HHS UL1RR024134
Abstract
objectiveTo describe patterns of treatment adherence to early maintenance phase therapy for acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL).
methodsUsing an objective observational method (electronic monitoring), adherence was examined for 139 patients aged 7-19 years diagnosed with ALL or LBL across 6 centers.
resultsThe mean adherence percentage was 86.2%. Adherence rates declined over the 1-month of follow-up to 83%. 3 linear trajectories of 6-mercaptopurine adherence were identified: (1) exemplary adherence (n = 99): Averaging nearly 100%; (2) deteriorating (n = 23): Adherence decreased from 100 to 60%; and (3) chronically poor adherence (n = 9): Averaging 40%.
conclusionsAdherence promotion interventions might be tailored to subgroups of patients who demonstrated problematic patterns of treatment adherence that could place them at risk for relapse. This research demonstrates the importance of using objective real-time measures of medication adherence for measuring and documenting adherence patterns.
Indexed as
Drug MonitoringAdolescentChildChild, PreschoolFemaleHumansMaleMedication AdherenceMercaptopurinePrecursor Cell Lymphoblastic Leukemia-LymphomaYoung AdultMercaptopurineadherencecancer and oncologyresearch design and methodsstatistical applications
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.