ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2014
Yield of undetected tuberculosis and human immunodeficiency virus coinfection from active case finding in urban Uganda.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 4 of them syntheses that pooled it.
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23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Differences in tuberculosis prevalence by sex in low- and middle-income countries over 1993-2025: A systematic review and meta-analysis.PLoS medicine · 2026Pooled it
- High HIV and active tuberculosis prevalence and increased mortality risk in adults with symptoms of TB: a systematic review and meta-analyses.Journal of the International AIDS Society · 2018Pooled it
- Interventions to increase tuberculosis case detection at primary healthcare or community-level services.The Cochrane database of systematic reviews · 2017Pooled it
- Sex Differences in Tuberculosis Burden and Notifications in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.PLoS medicine · 2016Pooled it
- AI-Driven Tuberculosis Hotspot Mapping to Optimize Active Case-Finding: Implementing the Epi-Control Platform in Uganda.Tropical medicine and infectious disease · 2026Article
- Importance of confirmatory test characteristics in optimizing community-based screening for tuberculosis: an epidemiological modeling analysis.BMC infectious diseases · 2025Article
- Article
- Capturing RecentTropical medicine and infectious disease · 2024Article
- Assessing a transmission network of Mycobacterium tuberculosis in an African city using single nucleotide polymorphism threshold analysis.MicrobiologyOpen · 2021Article
- Defining adequate contact for transmission of Mycobacterium tuberculosis in an African urban environment.BMC public health · 2020Article
- Yield of systematic household contact investigation for tuberculosis in a high-burden metropolitan district of South Africa.BMC public health · 2019Article
- Article
- Patient-led active tuberculosis case-finding in the Democratic Republic of the Congo.Bulletin of the World Health Organization · 2018Article
- Diagnostic yield of active case finding for tuberculosis and HIV at the household level in slums in Haiti.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Article
- Integrated Tuberculosis/Human Immunodeficiency Virus Community-Based Case Finding in Rural South Africa: Implications for Tuberculosis Control Efforts.Open forum infectious diseases · 2017Article
- A comparision of the yield of three tuberculosis screening modalities among people living with HIV: a retrospective quasi-experiemental study.BMC public health · 2016Article
- Higher cost of implementing Xpert(®) MTB/RIF in Ugandan peripheral settings: implications for cost-effectiveness.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2016Observational
- Prevalence of latent tuberculosis infection and associated risk factors in an urban African setting.BMC infectious diseases · 2015Article
- Rapid improvement in passive tuberculosis case detection and tuberculosis treatment outcomes after implementation of a bundled laboratory diagnostic and on-site training intervention targeting mid-level providers.Open forum infectious diseases · 2015Article
- Tuberculosis case finding in first-degree relative contacts not living with index tuberculosis cases in Kampala, Uganda.Clinical epidemiology · 2015Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo determine the yield of undetected active tuberculosis (TB), TB and human immunodeficiency virus (HIV) coinfection and the number needed to screen (NNS) to detect a case using active case finding (ACF) in an urban community in Kampala, Uganda.
methodsIn a door-to-door survey conducted in Rubaga community from January 2008 to June 2009, residents aged ≥15 years were screened for chronic cough (≥2 weeks) and tested for TB disease using smear microscopy and/or culture. Rapid testing was used to screen for HIV infection. The NNS to detect one case was calculated based on population screened and undetected cases found.
resultsOf 5102 participants, 3868 (75.8%) were females; the median age was 24 years (IQR 20-30). Of 199 (4%) with chronic cough, 160 (80.4%) submitted sputum, of whom 39 (24.4%, 95%CI 17.4-31.5) had undetected active TB and 13 (8.1%, 95%CI 6.7-22.9) were TB-HIV co-infected. The NNS to detect one TB case was 131 in the whole study population, but only five among the subgroup with chronic cough.
conclusionACF obtained a high yield of previously undetected active TB and TB-HIV cases. The NNS in the general population was 131, but the number needed to test in persons with chronic cough was five. These findings suggest that boosting the identification of persons with chronic cough may increase the overall efficiency of TB case detection at a community level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.