Evidence map›Paper›PMID 24365462›Full record

ArticleNeuroscience2014

Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB.

J Zhang, W Jiang, Z Zuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J ZhangDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, USA; Department of Anesthesiology, Shanghai 6th People's Hospital, Shanghai Jiaotong University, Shanghai, China.
W JiangDepartment of Anesthesiology, Shanghai 6th People's Hospital, Shanghai Jiaotong University, Shanghai, China. Electronic address: jiangw@sjtu.edu.en.
Z ZuoDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, USA. Electronic address: zz3c@virginia.edu.
University of Virginia · US

Funding

Volatile anesthetic modulation of glutamate transportersR01GM065211 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZUO, ZHIYI · 2003 to 2011
$2.6M
Volatile anesthetic effects on aging brainR01GM098308 · NIGMS · UNIVERSITY OF VIRGINIA · PI ZUO, ZHIYI · 2012 to 2015
$1.2M
NIGMS NIH HHS R01 GM065211NIGMS NIH HHS R01 GM098308
6 · The paper itself

Abstract

Surgery induces learning and memory impairment. Neuroinflammation may contribute to this impairment. Nuclear factor κB (NF-κB) is an important transcription factor to regulate the expression of inflammatory cytokines. We hypothesize that inhibition of NF-κB by pyrrolidine dithiocarbamate (PDTC) reduces neuroinflammation and the impairment of learning and memory. To test this hypothesis, four-month-old male Fischer 344 rats were subjected to right carotid exploration under propofol and buprenorphine anesthesia. Some rats received two doses of 50mg/kg PDTC given intraperitoneally 30min before and 6h after the surgery. Rats were tested in the Barnes maze and fear conditioning paradigm begun 6days after the surgery. Expression of various proteins related to inflammation was examined in the hippocampus at 24h or 21days after the surgery. Here, surgery, but not anesthesia alone, had a significant effect on prolonging the time needed to identify the target hole during the training sessions of the Barnes maze. Surgery also increased the time for identifying the target hole in the long-term memory test and decreased context-related learning and memory in fear conditioning test. Also, surgery increased nuclear expression of p65, a NF-κB component, decreased cytoplasmic amount of inhibitor of NF-κB, and increased the expression of interleukin-1β, interleukin-6, ionized calcium binding adaptor molecule 1 and active matrix metalloproteinase 9 (MMP-9). Finally, surgery enhanced IgG extravasation in the hippocampus. These surgical effects were attenuated by PDTC. These results suggest that surgery, but not propofol-based anesthesia, induces neuroinflammation and impairment of learning and memory. PDTC attenuates these effects possibly by inhibiting NF-κB activation and the downstream MMP-9 activity.

Indexed as

AnestheticsAnimalsBuprenorphineCarotid ArteriesCognition DisordersConditioning, PsychologicalEncephalitisFearHippocampusMaleMatrix Metalloproteinase 9Maze LearningNeuroprotective AgentsNF-kappa BPostoperative ComplicationsPropofolAnestheticsBuprenorphineMatrix Metalloproteinase 9Neuroprotective AgentsNF-kappa BPropofolpyrrolidine dithiocarbamic acidPyrrolidinesThiocarbamatesneuroinflammationnuclear factor κBpyrrolidine dithiocarbamateratsurgery

Identifiers

PMID24365462
PMCPMC3950371
OpenAlexW2063319790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.