Evidence map›Paper›PMID 24365076›Full record

ArticleBreast cancer research : BCR2013

Pygopus 2: tilting the Wnt-Notch balance in mammary epithelial lineage determination.

Kevin Roarty, Jeffrey M Rosen

Open access · goldAbstract readComment
In one paragraph

Article in Breast cancer research : BCR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kevin Roarty
Jeffrey M Rosen
Baylor College of Medicine · US

Funding

MALAT1 lncRNA as a Therapeutic Target in Triple Negative Breast CancerR01CA016303 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSEN, JEFFREY MARK · 1985 to 2022
$8.1M
HORMONAL REGULATION OF BREAST CANCERR37CA016303 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSEN, JEFFREY MARK · 1989 to 2011
$7.3M
NCI NIH HHS NCI-CA16303NCI NIH HHS R01 CA016303
6 · The paper itself

Abstract

The mammary gland requires the coordinated efforts of multiple epithelial cell lineages to build an organized bilayered ductal network. How epigenetic regulators direct decisions of cell-fate and lineage determination in cooperation with intrinsic transcriptional factors and extrinsic signaling factors remains a fundamental question in the field of developmental biology. Recent work sheds new light on the role of the histone methylation reader Pygopus 2 in coordinating the balance of self-renewal Wnt signals with luminal-specific Notch signals in mammary epithelial lineage determination.

Indexed as

Cell DifferentiationAnimalsEpithelial CellsFemaleIntracellular Signaling Peptides and ProteinsMaleMammary Glands, AnimalReceptors, NotchStem CellsWnt ProteinsIntracellular Signaling Peptides and ProteinsReceptors, NotchWnt Proteins

Identifiers

PMID24365076
PMCPMC3979041
OpenAlexW2095641167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.