ArticleBMC complementary and alternative medicine2013
Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 44 citations in OpenAlex.
- The Effect of Curcumin on Angiogenic and Proliferative Factors inHuman Endometriotic Cells.International journal of fertility & sterility · 2026Article
- Curcumin as a promising therapeutic agent for diabetic neuropathy: from molecular mechanisms to functional recovery.Diabetology & metabolic syndrome · 2025Review
- Inhibitive effect of Urginea epigea methanolic extract and silver/zinc oxide nanoparticles on Aspergillus and aflatoxin production.PloS one · 2025Article
- Neuroprotective role of curcumin on the hippocampus against the oxidative stress and inflammation of streptozotocin-induced diabetes in rats.Metabolic brain disease · 2024Article
- Article
- Investigating the potential role of swertiamarin on insulin resistant and non-insulin resistant granulosa cells of poly cystic ovarian syndrome patients.Journal of ovarian research · 2023Article
- Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats.Journal of cardiovascular and thoracic research · 2022Article
- The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications.Antioxidants (Basel, Switzerland) · 2021Review
- Regulatory Role of Nano-Curcumin against Tartrazine-Induced Oxidative Stress, Apoptosis-Related Genes Expression, and Genotoxicity in Rats.Molecules (Basel, Switzerland) · 2020Article
- Efficacy of melatonin in restoring the antioxidant status in the lens of diabetic rats induced by streptozotocin.Journal of diabetes and metabolic disorders · 2019Article
- Altered lipid metabolism in post-traumatic epileptic rat model: one proposed pathway.Molecular biology reports · 2019Article
- The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial.Diabetology & metabolic syndrome · 2019Article
- Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts.Molecular and cellular biochemistry · 2018Article
- Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus.Frontiers in pharmacology · 2018Review
- Role of Curcumin in Disease Prevention and Treatment.Advanced biomedical research · 2018Review
- PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review).Molecular medicine reports · 2017Review
- Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats.Scientific reports · 2017Article
- Neuroprotective role of curcumin on the hippocampus against the structural and serological alterations of streptozotocin-induced diabetes in Sprague Dawely rats.Iranian journal of basic medical sciences · 2017Article
- Database screening of herbal monomers regulating autophagy by constructing a "disease-gene-drug" network.BMC complementary and alternative medicine · 2014Article
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Authors and funding
1 author at 1 institution in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of curcumin on the activities and gene expression of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (G-ST), B-cell CLL/lymphoma 2 (Bcl-2) and insulin like growth factor-1 (IGF-1) in diabetic rats were studied.
methodsTwenty four rats were assigned to three groups (8 rats for each). Rats of first group were non diabetic and rats of the second group were rendered diabetic by streptozotocin (STZ). Both groups received vehicle, corn oil only (5 ml/kg body weight) and served as negative and positive controls, respectively. Rats of the third group were rendered diabetic and received oral curcumin dissolved in corn oil at a dose of 15 mg/5 ml/kg body weight for 6 weeks.
resultsDiabetic rats showed significant increase of blood glucose, thiobarbituric acid reactive substances (TBARS) and activities of all antioxidant enzymes with significant reduction of reduced glutathione (GSH) compare to the control non diabetic group. Gene expression of Bcl2, SOD, CAT, GPX and GST was increased significantly in diabetic untreated rats compare to the control non diabetic group. The administration of curcumin to diabetic rats normalized significantly their blood sugar level and TBARS values and increased the activities of all antioxidant enzymes and GSH concentration. In addition, curcumin treated rats showed significant increase in gene expression of IGF-1, Bcl2, SOD and GST compare to non diabetic and diabetic untreated rats.
conclusionCurcumin was antidiabetic therapy, induced hypoglycemia by up-regulation of IGF-1 gene and ameliorate the diabetes induced oxidative stress via increasing the availability of GSH, increasing the activities and gene expression of antioxidant enzymes and Bcl2. Further studies are required to investigate the actual mechanism of action of curcumin regarding the up regulation of gene expression of examined parameters.
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