ArticleLymphatic research and biology2013
Lymphatic pump treatment repeatedly enhances the lymphatic and immune systems.
Article in Lymphatic research and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03250312 (The Effects of Osteopathic Manipulations on the Expression Patterns of Immune Cell Biomarkers), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Osteopathic Manipulations on the Expression Patterns of Immune Cell Biomarkers
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Integrative Approaches to Atopic Dermatitis: Exploring Biomarkers, Current Therapies, and the Potential Role of Osteopathic Manipulative Medicine.International journal of molecular sciences · 2026Review
- Review
- Lymphatic pumping technique in mice alters blood parameters and metastatic melanoma in an age-dependent manner.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- A mechanistic hypothesis: osteopathic manipulative therapy may modulate immune cell function in chronic low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Osteopathic Manipulative Treatment Decreases Hospital Stay and Healthcare Cost in the Neonatal Intensive Care Unit.Medicines (Basel, Switzerland) · 2022Review
- Adjunctive osteopathic therapy for hospitalized COVID-19 patients: A feasibility-oriented chart review study with matched controls.International journal of osteopathic medicine : IJOM · 2022Article
- Osteopathic Manipulative Medicine: A Brief Review of the Hands-On Treatment Approaches and Their Therapeutic Uses.Medicines (Basel, Switzerland) · 2022Review
- Review
- Osteopathic Models Integration Radar Plot: A Proposed Framework for Osteopathic Diagnostic Clinical Reasoning.Journal of chiropractic humanities · 2021Review
- The Lymphatic System: An Osteopathic Review.Cureus · 2021Review
- Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease.The Journal of the American Osteopathic Association · 2019Article
- Sensitization and Interoception as Key Neurological Concepts in Osteopathy and Other Manual Medicines.Frontiers in neuroscience · 2016Review
- Low Lymphatic Pumping Pressure in the Legs Is Associated with Leg Edema and Lower Quality of Life in Healthy Volunteers.Lymphatic research and biology · 2015Article
- Risk of breast cancer recurrence in patients receiving manual lymphatic drainage: a hospital-based cohort study.Therapeutics and clinical risk management · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundOsteopathic practitioners utilize manual therapies called lymphatic pump techniques (LPT) to treat edema and infectious diseases. While previous studies examined the effect of a single LPT treatment on the lymphatic system, the effect of repeated applications of LPT on lymphatic output and immunity has not been investigated. Therefore, the purpose of this study was to measure the effects of repeated LPT on lymphatic flow, lymph leukocyte numbers, and inflammatory mediator concentrations in thoracic duct lymph (TDL). METHODS AND
resultsThe thoracic ducts of five mongrel dogs were cannulated, and lymph samples were collected during pre-LPT, 4 min of LPT, and 2 hours post-LPT. A second LPT (LPT-2) was applied after a 2 hour rest period. TDL flow was measured, and TDL were analyzed for the concentration of leukocytes and inflammatory mediators. Both LPT treatments significantly increased TDL flow, leukocyte count, total leukocyte flux, and the flux of interleukin-8 (IL-8), keratinocyte-derived chemoattractant (KC), nitrite (NO2(-)), and superoxide dismutase (SOD). The concentration of IL-6 increased in lymph over time in all experimental groups; therefore, it was not LPT dependent.
conclusionClinically, it can be inferred that LPT at a rate of 1 pump per sec for a total of 4 min can be applied every 2 h, thus providing scientific rationale for the use of LPT to repeatedly enhance the lymphatic and immune system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.