Trial reportJournal of abnormal psychology2013
Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation.
Trial report in Journal of abnormal psychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Naltrexone and alcohol effects on craving for cigarettes in heavy drinking smokers.Experimental and clinical psychopharmacology · 2019Trial
- Mecamylamine treatment for alcohol dependence: a randomized controlled trial.Addiction (Abingdon, England) · 2018Trial
- The effects of alcohol-containing e-cigarettes on young adult smokers.Drug and alcohol dependence · 2016Trial
- Varenicline, low dose naltrexone, and their combination for heavy-drinking smokers: human laboratory findings.Psychopharmacology · 2014Trial
- Effects of nicotine-alcohol co-use on alcohol-induced blackouts and other alcohol-related consequences in college students.Psychopharmacology · 2025Article
- Public attitudes about the support for the establishment of smoke-free environment.Frontiers in public health · 2025Article
- Simultaneous use of alcohol and cigarettes in a mixed psychiatric sample: Daily-life associations with smoking motives, craving, stimulation, sedation, and affect.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
- Addiction-Related Outcomes of Nicotine and Alcohol Co-use: New Insights Following the Rise in Vaping.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Review
- Combined smoking and alcohol cues: Effects on craving, drug-seeking, and consumption.Alcoholism, clinical and experimental research · 2021Article
- Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users.Epigenomes · 2021Article
- A Retrospective Analysis of Chemical Constituents in Regulated and Unregulated E-Cigarette Liquids.Frontiers in chemistry · 2021Article
- Article
- Lack of utility of cigarettes per day cutoffs for clinical and laboratory smoking research.Addictive behaviors · 2019Article
- GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- An overview of alcohol and tobacco/nicotine interactions in the human laboratory.The American journal of drug and alcohol abuse · 2017Review
- Psychopharmacology of Tobacco and Alcohol Comorbidity: a Review of Current Evidence.Current addiction reports · 2017Review
- Attentional bias to smoking and other motivationally relevant cues is affected by nicotine exposure and dose expectancy.Journal of psychopharmacology (Oxford, England) · 2016Article
- Current insights into the mechanisms and development of treatments for heavy drinking cigarette smokers.Current addiction reports · 2016Article
- Cognitive manifestations of drinking-smoking associations: preliminary findings with a cross-primed Stroop task.Drug and alcohol dependence · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
An extensive literature documents a close association between cigarette and alcohol use. The joint pharmacological effects of alcohol and nicotine on smoking and drinking motivation may help explain this relationship. This experiment was designed to test the separate and combined pharmacological effects of nicotine and a low dose of alcohol (equivalent to 1-2 standard drinks) on substance use motivation using a double-blind and fully crossed within-subjects design. Participants (N = 87) with a wide range of smoking and drinking patterns completed 4 counterbalanced experimental sessions during which they consumed an alcohol (male: 0.3g/kg; female: 0.27g/kg) or placebo beverage and smoked a nicotine (.6 mg) or placebo cigarette. Outcome measures assessed the impact of drug administration (alcohol or nicotine) on craving to smoke, craving to drink, affect, and liking of the beverage and cigarette. Results indicated that combined administration produced higher cravings to smoke for the entire sample, as well as higher cravings to drink among women and lighter drinkers. Heavier users of either alcohol or cigarettes also exhibited enhanced sensitivity to the effects of either drug in isolation. Separate, but not interactive, effects of alcohol and nicotine on mood were observed as well as both same-drug and cross-drug effects on beverage and cigarette liking. Together, these findings support the notion that the interactive pharmacological effects of nicotine and low doses of alcohol play an important role in motivating contemporaneous use and suggest roles for cross-reinforcement and cross-tolerance in the development and maintenance of alcohol and nicotine use and dependence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.