ArticleBrain and behavior2013
Thalamo-striato-cortical determinants to fatigue in multiple sclerosis.
Article in Brain and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
- Functional connectivity modifications in monoaminergic circuits occur in fatigued MS patients treated with fampridine and amantadine.Journal of neurology · 2023Trial
- Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.Scientific reports · 2019Trial
- Investigating the Relationship Between Visual Evoked Potentials, Neurological and Neuropsychological Status in Primary Progressive Multiple Sclerosis.Journal of clinical medicine · 2026Article
- Among common neuropsychological tests, the Paced auditory serial addition test is the strongest predictor of trait fatigue in patients with traumatic brain injury.Journal of neuropsychology · 2025Article
- Monoaminergic network abnormalities are associated with fatigue in pediatric multiple sclerosis.Journal of neurology · 2024Article
- Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis.Molecular psychiatry · 2024Article
- Cortical-striatal network functional connectivity markers in poststroke fatigue: a single-centre fMRI case-control study protocol.BMJ open · 2024Article
- Understanding the mechanisms of fatigue in multiple sclerosis: linking interoception, metacognition and white matter dysconnectivity.Brain communications · 2024Article
- Aberrant voxel-based degree centrality and functional connectivity in Parkinson's disease patients with fatigue.CNS neuroscience & therapeutics · 2023Article
- Structural and functional magnetic resonance imaging correlates of fatigue and dual-task performance in progressive multiple sclerosis.Journal of neurology · 2023Article
- Shared imaging markers of fatigue across multiple sclerosis, aquaporin-4 antibody neuromyelitis optica spectrum disorder and MOG antibody disease.Brain communications · 2023Article
- Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis.The Journal of experimental medicine · 2022Article
- Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes.Neurology and therapy · 2022Review
- Multisensory mental imagery of fatigue: Evidence from an fMRI study.Human brain mapping · 2022Article
- The Neurobiology of Pathological Fatigue: New Models, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Associations of White Matter and Basal Ganglia Microstructure to Cognitive Fatigue Rate in Multiple Sclerosis.Frontiers in neurology · 2022Article
- Multiple sclerosis-related fatigue lacks a unified definition: A narrative review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
- Cognitive fatigue in multiple sclerosis is associated with alterations in the functional connectivity of monoamine circuits.Brain communications · 2021Article
- Prevalence and predictors of fatigue after aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2020Article
- Changes of central noradrenaline transporter availability in immunotherapy-naïve multiple sclerosis patients.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim was to explore the thalamo-striato-cortical theory of central fatigue in multiple sclerosis (MS) patients with self-reported fatigue. If the theory correctly predicted fatigue based on disruptions of the thalamo-striato-cortical network, we expected altered brain activation in this network in MS participants while performing a complex cognitive task that challenged fatigue.
methodsMS participants with self-reported fatigue were examined by functional magnetic resonance imaging (fMRI) during the performance of a complex working memory task. In this task, cognitive effort was challenged by a parametric design, which modeled the cerebral responses at increasing cognitive demands. In order to explore the theory of central fatigue in MS we also analyzed the cerebral responses by adding perceived fatigue scores as covariates in the analysis and by calculating the functional connectivity between regions in the thalamo-striatocortical network. The main findings were that MS participants elicited altered brain responses in the thalamo-striato-cortical network, and that brain activation in the left posterior parietal cortex and the right substantia nigra was positively correlated to perceived fatigue ratings. MS participants had stronger cortical-to-cortical and subcortical-to-subcortical connections, whereas they had weaker cortical-to-subcortical connections.
conclusionsThe findings of the present study indicate that the thalamo-striato-cortical network is involved in the pathophysiology of fatigue in MS, and provide support for the theory of central fatigue. However, due to the limited number of participants and the somewhat heterogeneous sample of MS participants, these results have to be regarded as tentative, though they might serve as a basis for future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.