ArticleJournal of the Pediatric Infectious Diseases Society2013
Home Self-Collection of Nasal Swabs for Diagnosis of Acute Respiratory Virus Infections in Children With Cystic Fibrosis.
Article in Journal of the Pediatric Infectious Diseases Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections.Clinical microbiology reviews · 2019Guideline
- A novel anterior nasal swab to detect respiratory viruses: a prospective study of diagnostic accuracy.BMC pediatrics · 2023Trial
- Effectiveness of Self-Collected, Ambient Temperature-Preserved Nasal Swabs Compared to Samples Collected by Trained Staff for Genotyping of Respiratory Viruses by Shotgun RNA Sequencing: Comparative Study.JMIR formative research · 2023Article
- Acceptability, Feasibility, and Validity of Detecting Respiratory Pathogens During Acute Respiratory Illness in Participant-Collected Swabs in a Low-Income, Community Sample.Open forum infectious diseases · 2023Article
- Human bocavirus-1 infections in Australian children aged < 2 years: a birth cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- SwabExpress: An End-to-End Protocol for Extraction-Free COVID-19 Testing.Clinical chemistry · 2021Article
- SwabExpress: An end-to-end protocol for extraction-free COVID-19 testing.bioRxiv : the preprint server for biology · 2021Article
- Clinical impact of respiratory virus in pulmonary exacerbations of children with Cystic Fibrosis.PloS one · 2020Article
- Article
- Early respiratory viral infections in infants with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2019Observational
- Viral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study.Virology journal · 2019Article
- Evaluating addition of self-collected throat swabs to nasal swabs for respiratory virus detection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- A patient self-collection method for longitudinal monitoring of respiratory virus infection in solid organ transplant recipients.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundUnderstanding the importance of respiratory viruses in children with cystic fibrosis (CF) has been limited because of challenges using clinic- or hospital-based diagnostic testing. We conducted a pilot study to assess feasibility of home self- (or parent-) collection of nasal swabs (NS).
methodsCystic fibrosis patients aged 6-18 years with new respiratory illness participated. In clinic, a deep nasal flocked swab was collected by research staff and compared with an anterior foam NS obtained after instillation of saline spray. At home, up to 2 self-collections of paired foam NS (with and without saline) were collected and mailed for real-time polymerase chain reaction (PCR) testing.
resultsPaired swabs were collected from 28 patients: 18 sets in clinic (deep nasal vs saline foam NS) and 43 sets at home (saline vs dry foam NS) with 9 (50%) and 35 (81%) virus detections, respectively. Home-collected NS were obtained closer to illness onset, with a mean difference in symptom days of -2.3 between home and clinic collections (95% confidence interval [CI] -3.5, -1.2; P < .001). Rhinovirus comprised 73% of virus detections; the difference in mean PCR cycle threshold values for rhinovirus between swabs collected at home versus clinic was -3.8 (95% CI -6.8, -0.9; P = .014), indicating significantly higher viral load for home-collected swabs.
conclusionsHome-collected foam NS had a higher positivity rate compared with clinic-collected swabs, likely because collection was closer to illness onset. Home self-collection is feasible and well tolerated for timely respiratory virus diagnosis and provides a novel approach for clinical diagnostics and surveillance of respiratory virus infections among CF patients.
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Registered trials
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