ArticleOxidative medicine and cellular longevity2013
Superoxide dismutase1 levels in North Indian population with age-related macular degeneration.
Article in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Antioxidants and Mechanistic Insights for Managing Dry Age-Related Macular Degeneration.Antioxidants (Basel, Switzerland) · 2024Review
- Oxidative Stress and Antioxidants in Age-Related Macular Degeneration.Antioxidants (Basel, Switzerland) · 2023Review
- Modulated anti-VEGF therapy under the influence of lipid metabolizing proteins in Age related macular degeneration: a pilot study.Scientific reports · 2022Article
- Article
- The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health.International journal of environmental research and public health · 2019Review
- CCL2 single nucleotide polymorphism of rs1024611 implicates prominence of inflammatory cascade by univariate modeling in Indian AMD.PloS one · 2018Article
- Article
- Serum vascular endothelial growth factor receptor-2 and adropin levels in age-related macular degeneration.International journal of ophthalmology · 2016Article
- Exploring the role of VEGF in Indian Age related macular degeneration.Annals of neurosciences · 2015Article
- The reduction of serum soluble Flt-1 in patients with neovascular age-related macular degeneration.American journal of ophthalmology · 2015Article
- Revisiting the dilution factor as vital parameter for sensitivity of ELISA assay in CSF and Plasma.Annals of neurosciences · 2015Article
- Bax modulates neuronal survival while p53 is unaltered after Cytochrome C induced oxidative stress in the adult olfactory bulb in vivo.Annals of neurosciences · 2015Article
- Association of age-related macular degeneration with erythrocyte antioxidant enzymes activity and serum total antioxidant status.Oxidative medicine and cellular longevity · 2015Article
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6 authors.
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Abstract
aimThe aim of the study was to estimate the levels of superoxide dismutase1 (SOD1) in patients of age-related macular degeneration (AMD) and examine the role of oxidative stress, smoking, hypertension, and other factors involved in the pathogenesis of AMD.
methods115 AMD patients and 61 healthy controls were recruited for this study. Serum SOD1 levels were determined by ELISA and were correlated to various risk factors. Logistic regression model of authenticity, by considering SOD1 as independent variable, has been developed along with ROC curve.
resultsThe SOD1 levels were significantly higher in AMD patients as compared to those of the controls. The difference was not significant for wet and dry AMD. However, the difference was significant between wet AMD subtypes. Nonsignificance of the Hosmer-Lemeshow goodness of fit statistic (χ(2) = 10.516, df = 8, P = 0.231) indicates the appropriateness of logistic regression model to predict AMD.
conclusionOxidative stress in AMD patients may mount compensatory response resulting in increased levels of SOD1 in AMD patients. To predict the risk of AMD on the basis of SOD1, a logistic regression model shows authenticity of 78%, and area under the ROC curve (0.827, P = .0001) with less standard error of 0.033 coupled with 95% confidence interval of 0.762-0.891 further validates the model.
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