Evidence map›Paper›PMID 24363760›Full record

ArticleClinical & developmental immunology2013

The effect of perioperative immunonutrition on the phagocytic activity of blood platelets in advanced gastric cancer patients.

Zbigniew Kamocki, Joanna Matowicka-Karna, Mariusz Gryko, Konrad Zareba, Boguslaw Kedra, Halina Kemona

Registry-linked trialAbstract read
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In one paragraph

Article in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01704664 (Prospective Study of the Effect of Perioperative Immunonutrition on the Immune Host Defense and the Phagocytic and Bactericidal Activity of Blood Platelets in Gastric Cancer Patients.), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01704664 naunknown statusnot on this map

Prospective Study of the Effect of Perioperative Immunonutrition on the Immune Host Defense and the Phagocytic and Bactericidal Activity of Blood Platelets in Gastric Cancer Patients.

TypeinterventionalSponsorMedical University of BialystokRan2007 to 2022Enrolled240ConditionsGastric CancerArmsEarly postoperative enteral nutrition, based on standard elementary diet (Peptisorb), glutamine, oral diet enriched with arginine (Cubitan), Perioperative parenteral immunonutrition (Dipeptiven, Omegaven)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zbigniew Kamocki2nd Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A Street, 15-276 Bialystok, Poland.
Joanna Matowicka-KarnaDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland.
Mariusz Gryko2nd Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A Street, 15-276 Bialystok, Poland.
Konrad Zareba2nd Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A Street, 15-276 Bialystok, Poland.
Boguslaw Kedra2nd Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A Street, 15-276 Bialystok, Poland.
Halina KemonaDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPerioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer.

methods51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed. Patients of groups I and II underwent palliative gastrectomy. Patients of groups III and IV had exploratory laparotomy. Perioperative immunonutrition was administered as follows: group I--TPN, II--oral arginine, peripheral TPN, III--TPN preoperatively, and IV--without nutrition. The phagocytic activity of blood platelets was determined before and after nutritional therapy and was assessed by measuring the fraction of phagocytic thrombocytes (%phag) and the phagocytic index (Ixphag).

resultsThe percentage of phagocytizing platelets and the phagocytic index prior to and after the surgery amounted to the following: group I--1.136-1.237, P = NS, and 1.007-1.1, P = NS, respectively, II--1.111-1.25, P < 0.05, and 1.011-1.083, P < 0.05, III--1.112-1.186, P = NS, and 0.962-1.042, P = NS, and IV--1.085-0.96, P = NS, and 1.023-1.04, P = NS.

conclusionsThe phagocytic activity of platelets in patients with advanced gastric cancer is significantly impaired. Perioperative immunonutrition with oral arginine-rich diet can partially improve the phagocytic activity of blood platelets. This trial is registered with Clinicaltrials.gov--NCT01704664.

Indexed as

AdolescentAdultAgedAged, 80 and overBlood PlateletsBody Mass IndexCase-Control StudiesFemaleGastrectomyHumansMaleMiddle AgedNeoplasm StagingNutritional StatusPerioperative PeriodPhagocytosis

Identifiers

PMID24363760
PMCPMC3864072

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