Evidence map›Paper›PMID 24363647›Full record

ReviewFrontiers in psychiatry2013

Deep brain stimulation as a tool for improving cognitive functioning in Alzheimer's dementia: a systematic review.

Katja Hardenacke, Elena Shubina, Christian Philipp Bührle, Alexandra Zapf, Doris Lenartz, Joachim Klosterkötter, Veerle Visser-Vandewalle, Jens Kuhn

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 68 citations in OpenAlex.

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  5. Advances in the study of cholinergic circuits in the central nervous system.Annals of clinical and translational neurology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Katja HardenackeDepartment of Psychiatry and Psychotherapy, University of Cologne , Cologne , Germany.
Elena ShubinaDepartment of Psychiatry and Psychotherapy, University of Cologne , Cologne , Germany.
Christian Philipp BührleDepartment of Stereotactic and Functional Neurosurgery, University of Cologne , Cologne , Germany.
Alexandra ZapfDepartment of Psychiatry and Psychotherapy, University of Cologne , Cologne , Germany.
Doris LenartzDepartment of Stereotactic and Functional Neurosurgery, University of Cologne , Cologne , Germany.
Joachim KlosterkötterDepartment of Psychiatry and Psychotherapy, University of Cologne , Cologne , Germany.
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, University of Cologne , Cologne , Germany.
Jens KuhnDepartment of Psychiatry and Psychotherapy, University of Cologne , Cologne , Germany.
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) is an established, in selected cases therapeutically effective, non-lesional treatment method delivering current rectangular pulses into dysfunctional brain structures via chronically implanted stimulation electrodes. DBS is a recognized method applied in movement disorders and is increasingly evaluated as a possible therapeutic option for psychiatric diseases such as refractory obsessive-compulsive disorders, Gilles de la Tourette syndrome, major depression, and substance-related addiction. Latest research indicates that DBS may be a method for improving cognitive functions in Alzheimer's dementia (AD). Translational data in healthy and AD animals appear to support this notion. Nevertheless, many aspects remain unclear, particularly with regard to the optimal target structure. The objective of this review is to present a systematic overview regarding published research on DBS and cognitive functioning in animal and human studies as well as to provide a systematic overview of the feasibility and efficacy of the treatment. We describe three studies investigating the effects of DBS in patients with dementia, using either the fornix or the nucleus basalis of Meynert (NBM) as a target. In total, we identified 25 animal studies with 10 brain structures being targeted: fornix, NBM, anterior caudate nucleus, dorsal striatum, anterior thalamic nucleus, midline thalamic nuclei, central thalamus, lateral hypothalamus, hippocampus (entorhinal cortex, perforant path), and amygdala. Considering the wide and diverse spectrum of targets, we add to this review a supposition about possible underlying mechanisms of operation and recommendations for further research.

Indexed as

Alzheimer’s diseaseanimal modelscognitiondeep brain stimulationdementiamemorytarget selection

Identifiers

PMID24363647
PMCPMC3850165
OpenAlexW2070799562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.