ReviewFrontiers in psychiatry2013
Pharmacological Interventions for the MATRICS Cognitive Domains in Schizophrenia: What's the Evidence?
Review in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- [Schizophrenia and bipolar disorder : Treatment of cognitive impairments].Der Nervenarzt · 2018Pooled it
- Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study.Journal of psychopharmacology (Oxford, England) · 2020Trial
- Gender differences in cognitive improvements after two months of atypical antipsychotic treatment in first episode schizophrenia.Frontiers in psychiatry · 2024Article
- Association of Alexithymia With Positive Symptoms in Chinese Chronic Schizophrenia Patients With and Without Obesity.Psychiatry investigation · 2023Article
- The role of the insula in cognitive impairment of schizophrenia.Schizophrenia research. Cognition · 2023Review
- ARAS recent onset acute phase psychosis survey, a prospective observational cohort of first episode psychosis in Iran-the cohort profile.Schizophrenia (Heidelberg, Germany) · 2022Article
- Prevalence, profile and associations of cognitive impairment in Ugandan first-episode psychosis patients.Schizophrenia research. Cognition · 2022Article
- From the Clinic to the Laboratory, and Back Again: Investigations on Cannabinoids and Endocannabinoid System Modulators for Treating Schizophrenia.Frontiers in psychiatry · 2021Review
- Commentary: Composite cognitive and functional measures for early stage Alzheimer's disease trials.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Cognition and Related Neural Findings on Methamphetamine Use Disorder: Insights and Treatment Implications From Schizophrenia Research.Frontiers in psychiatry · 2019Review
- Competence to Consent and Its Relationship With Cognitive Function in Patients With Schizophrenia.Frontiers in psychiatry · 2019Review
- Relationship between muscarinic MNeuroImage. Clinical · 2018Article
- MK-801-induced impairments on the trial-unique, delayed nonmatching-to-location task in rats: effects of acute sodium nitroprusside.Psychopharmacology · 2017Article
- Developmental vitamin D deficiency and schizophrenia: the role of animal models.Genes, brain, and behavior · 2016Review
- Comparing the effects of subchronic phencyclidine and medial prefrontal cortex dysfunction on cognitive tests relevant to schizophrenia.Psychopharmacology · 2015Article
- Neural Substrates of Dopamine D2 Receptor Modulated Executive Functions in the Monkey Prefrontal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance.PloS one · 2015Article
- Prefrontal dopamine in associative learning and memory.Neuroscience · 2014Review
- Neuropsychopharmacology of psychosis: relation of brain signals, cognition, and chemistry.Frontiers in psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a disabling, chronic psychiatric disorder with a prevalence rate of 0.5-1% in the general population. Symptoms include positive (e.g., delusions, hallucinations), negative (e.g., blunted affect, social withdrawal), as well as cognitive symptoms (e.g., memory and attention problems). Although 75-85% of patients with schizophrenia report cognitive impairments, the underlying neuropharmacological mechanisms are not well understood and currently no effective treatment is available for these impairments. This has led to the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative, which established seven cognitive domains that are fundamentally impaired in schizophrenia. These domains include verbal learning and memory, visual learning and memory, working memory, attention and vigilance, processing speed, reasoning and problem solving, and social cognition. Recently, a growing number of studies have been conducted trying to identify the underlying neuropharmacological mechanisms of cognitive impairments in schizophrenia patients. Specific cognitive impairments seem to arise from different underlying neuropharmacological mechanisms. However, most review articles describe cognition in general and an overview of the mechanisms involved in these seven separate cognitive domains is currently lacking. Therefore, we reviewed the underlying neuropharmacological mechanisms focusing on the domains as established by the MATRICS initiative which are considered most crucial in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.