ArticlePLoS computational biology2013
A Petri net model of granulomatous inflammation: implications for IL-10 mediated control of Leishmania donovani infection.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis.Journal of extracellular vesicles · 2026Article
- Ontogeny independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis.Communications biology · 2026Article
- Review
- Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots.International journal of molecular sciences · 2023Review
- Spatially Resolved Immunometabolism to Understand Infectious Disease Progression.Frontiers in microbiology · 2021Article
- A Role of Inflammation and Immunity in Essential Hypertension-Modeled and Analyzed Using Petri Nets.International journal of molecular sciences · 2020Article
- Neutrophil elastase promotesFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action.Frontiers in immunology · 2019Article
- Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology.Immunological reviews · 2018Review
- New advances in the development of sarcoidosis models: a synopsis of a symposium sponsored by the Foundation for Sarcoidosis Research.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Macrophage Transactivation for Chemokine Production Identified as a Negative Regulator of Granulomatous Inflammation Using Agent-Based Modeling.Frontiers in immunology · 2018Article
- Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development.CPT: pharmacometrics & systems pharmacology · 2017Review
- Lessons from other diseases: granulomatous inflammation in leishmaniasis.Seminars in immunopathology · 2016Review
- The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis.Frontiers in immunology · 2016Review
- Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease.Journal of immunology research · 2016Review
- Identification of Th1/Th2 regulatory switch to promote healing response during leishmaniasis: a computational approach.EURASIP journal on bioinformatics & systems biology · 2015Article
- Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.Infection and immunity · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Experimental visceral leishmaniasis, caused by infection of mice with the protozoan parasite Leishmania donovani, is characterized by focal accumulation of inflammatory cells in the liver, forming discrete "granulomas" within which the parasite is eventually eliminated. To shed new light on fundamental aspects of granuloma formation and function, we have developed an in silico Petri net model that simulates hepatic granuloma development throughout the course of infection. The model was extensively validated by comparison with data derived from experimental studies in mice, and the model robustness was assessed by a sensitivity analysis. The model recapitulated the progression of disease as seen during experimental infection and also faithfully predicted many of the changes in cellular composition seen within granulomas over time. By conducting in silico experiments, we have identified a previously unappreciated level of inter-granuloma diversity in terms of the development of anti-leishmanial activity. Furthermore, by simulating the impact of IL-10 gene deficiency in a variety of lymphocyte and myeloid cell populations, our data suggest a dominant local regulatory role for IL-10 produced by infected Kupffer cells at the core of the granuloma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.