Evidence map›Paper›PMID 24363556›Full record

ReviewInternational journal of nanomedicine2014

Nanotechnology-based drug delivery systems and herbal medicines: a review.

Bruna Vidal Bonifácio, Patricia Bento da Silva, Matheus Aparecido Dos Santos Ramos, Kamila Maria Silveira Negri, Taís Maria Bauab, Marlus Chorilli

Open access · goldAbstract readReview
In one paragraph

Review in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 670 citations in OpenAlex.

  1. Understanding the Effect of Propolis and Its Derivatives AgainstJournal of fungi (Basel, Switzerland) · 2026
    Review
  2. Liquid crystalline system for drug delivery: structural insights, preparation techniques and translational potential.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  3. International journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Cytotoxicity ofInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Nanoliposomal Formulation ofFood science & nutrition · 2025
    Article
  14. Formulation and Optimization of aGels (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Review
  17. Chemical Composition and Biological Activities ofMolecules (Basel, Switzerland) · 2025
    Review
  18. Review
  19. Article
  20. Article

125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bruna Vidal BonifácioSchool of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.
Patricia Bento da SilvaSchool of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.
Matheus Aparecido Dos Santos RamosSchool of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.
Kamila Maria Silveira NegriSchool of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.
Taís Maria BauabSchool of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.
Marlus ChorilliSchool of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.

Indexed as

AnimalsDrug DesignHerbal MedicineHumansNanocapsulesNanotechnologyPhytotherapyPlant ExtractsPlants, MedicinalNanocapsulesPlant Extractsbiological activitydrug delivery systemsherbal medicinesnanotechnologynatural products

Identifiers

PMID24363556
PMCPMC3862741
OpenAlexW2023834592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.