ArticleWorld journal of gastroenterology2013
Association of visceral obesity and early colorectal neoplasia.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Adiposity associations with risk of colorectal cancer: a systematic review.Obesity (Silver Spring, Md.) · 2025Pooled it
- Association between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects.European journal of epidemiology · 2018Pooled it
- Blood Lipid Concentrations and Colorectal Adenomas: A Systematic Review and Meta-Analysis of Colonoscopy Studies in Asia, 2000-2014.American journal of epidemiology · 2016Pooled it
- Converted Macrophage Polarization and Expression of COL6α3-Early Predictors of Remodeling Processes in Adipose Tissue of Male Children.Biomedicines · 2025Article
- Deep learning imaging phenotype can classify metabolic syndrome and is predictive of cardiometabolic disorders.Journal of translational medicine · 2024Article
- Article
- Association between android fat mass, gynoid fat mass and cardiovascular and all-cause mortality in adults: NHANES 2003-2007.Frontiers in cardiovascular medicine · 2023Article
- DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer.Epigenetics · 2022Article
- Role of Perirectal Fat in the Carcinogenesis and Development of Early-Onset Rectal Cancer.Journal of oncology · 2022Article
- Article
- Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study.Cancer causes & control : CCC · 2020Article
- Is visceral obesity associated with colorectal cancer? The first volumetric study using all CT slices.Diagnostic and interventional radiology (Ankara, Turkey) · 2019Article
- Clinical stages of colorectal cancer diagnosed in obese and overweight individuals in the Polish Colonoscopy Screening Program.United European gastroenterology journal · 2019Article
- Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer.Intestinal research · 2019Article
- Evolving notions on immune response in colorectal cancer and their implications for biomarker development.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy.World journal of gastroenterology · 2016Observational
- Obesity and colorectal cancer: molecular features of adipose tissue.Journal of translational medicine · 2016Review
- Effect of a high-fat diet in development of colonic adenoma in an animal model.World journal of gastroenterology · 2014Article
- Impact of Abdominal Adipose Depots and Race on Risk for Colorectal Cancer: A Case-Control Study.Nutrition and cancerArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine whether visceral adipose tissue (VAT) serves as a risk factor for colorectal adenoma-early colorectal cancer (CRC) sequence.
methodsA retrospective case-control study was conducted with 153 patients with stage I CRC, age/sex-matched 554 patients with colorectal adenoma and 557 normal controls. All subjects underwent various laboratory tests, abdominal fat computed tomography (CT), and colonoscopy. VAT was defined as an intra-abdominal adipose tissue area measured by CT scan. Adipose tissue area was measured at the level of the umbilicus from CT scan. We used the lowest quartile of VAT and subcutaneous adipose tissue area as a reference group.
resultsThe body mass index (BMI), total cholesterol, fasting glucose and VAT areas were significantly different among normal, adenoma and CRC groups. The VAT area was 120.6 ± 49.0 cm(2) in normal controls, 130.6 ± 58.4 cm(2) in adenoma group and 117.6 ± 51.6 cm(2) in CRC group (P = 0.002). In univariate analysis, increased BMI was a risk factor for CRC compared to control (P = 0.025). However, VAT area was not a risk factor for CRC compared to control. In multivariate analysis that adjusted for smoking, alcohol consumption and subcutaneous adipose tissue area, VAT area was inversely related to CRC, compared to the adenoma (OR = 0.53, 95%CI: 0.31-0.92, highest quartile vs lowest quartile).
conclusionOur study shows that visceral obesity is not a risk factor for early CRC. Visceral obesity might influence the normal-adenoma sequence but not the adenoma-early carcinoma sequence.
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