Evidence map›Paper›PMID 24363499›Full record

ArticleMediators of inflammation2013

Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1β in osteoarthritic chondrocytes.

Julia Platas, Maria Isabel Guillén, María Dolores Pérez del Caz, Francisco Gomar, Vicente Mirabet, Maria José Alcaraz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  11. Advances in Stem Cell-Based Therapies in the Treatment of Osteoarthritis.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Julia PlatasDepartment of Pharmacology, University of Valencia, Avenue Vicent Andrés Estellés s/n, Burjassot, 46100 Valencia, Spain.
Maria Isabel GuillénDepartment of Pharmacology, University of Valencia, Avenue Vicent Andrés Estellés s/n, Burjassot, 46100 Valencia, Spain ; Department of Pharmacy, Cardenal Herrera CEU University, Moncada, 46113 Valencia, Spain.
María Dolores Pérez del CazDepartment of Burn and Plastic Surgery, La Fe University Hospital, 46026 Valencia, Spain.
Francisco GomarDepartment of Surgery, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Vicente MirabetValencia Transfusion Center, Generalitat Valenciana, 46014 Valencia, Spain.
Maria José AlcarazDepartment of Pharmacology, University of Valencia, Avenue Vicent Andrés Estellés s/n, Burjassot, 46100 Valencia, Spain.
Universitat de València · ESGeneralitat Valenciana · ESHospital Universitari i Politècnic La Fe · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is the most frequent joint disorder and an important cause of disability. Recent studies have shown the potential of adipose-tissue-derived mesenchymal stem cells (AD-MSC) for cartilage repair. We have investigated whether conditioned medium from AD-MSC (CM) may regulate in OA chondrocytes a number of key mediators involved in cartilage degeneration. CM enhanced type II collagen expression in OA chondrocytes while decreasing matrix metalloproteinase (MMP) activity in cell supernatants as well as the levels of MMP-3 and MMP-13 proteins and mRNA in OA chondrocytes stimulated with interleukin- (IL-) 1β. In addition, CM increased IL-10 levels and counteracted the stimulating effects of IL-1β on the production of tumor necrosis factor-α, IL-6, prostaglandin E2, and NO measured as nitrite and the mRNA expression of these cytokines, CCL-2, CCL-3, CCL-4, CCL-5, CCL-8, CCL-19, CCL-20, CXCL-1, CXCL-2, CXCL-3, CXCL-5, CXCL-8, cyclooxygenase-2, microsomal prostaglandin E synthase-1, and inducible NO synthase. These effects may be dependent on the inhibition of nuclear factor-κB activation by CM. Our data demonstrate the chondroprotective actions of CM and provide support for further studies of this approach in joint disease.

Indexed as

Adipose TissueAgedCells, CulturedChondrocytesCollagen Type IICulture Media, ConditionedDown-RegulationFemaleHumansInflammation MediatorsInterleukin-1betaInterleukin-6MaleMatrix Metalloproteinase 13Matrix Metalloproteinase 3Mesenchymal Stem CellsCollagen Type IICulture Media, ConditionedInflammation MediatorsInterleukin-1betaInterleukin-6Matrix Metalloproteinase 13Matrix Metalloproteinase 3NF-kappa BNitric OxideTumor Necrosis Factor-alpha

Identifiers

PMID24363499
PMCPMC3864089
OpenAlexW2163538853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.