Evidence map›Paper›PMID 24363496›Full record

ArticleJournal of modern optics2012

Functional imaging of glucose-evoked rat islet activities using transient intrinsic optical signals.

Xin-Cheng Yao, Wan-Xing Cui, Yi-Chao Li, Wei Zhang, Rong-Wen Lu, Anthony Thompson, Franklin Amthor, Xu-Jing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of modern optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin-Cheng YaoDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Wan-Xing CuiDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Yi-Chao LiDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Wei ZhangDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rong-Wen LuDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Anthony ThompsonDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Franklin AmthorDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Xu-Jing WangDepartment of Physics, University of Alabama at Birmingham, Birmingham, AL 35294, USA ; The Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
UAB Diabetes Research and Training CenterP60DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GARVEY, W TIMOTHY · 2008 to 2012
$8.4M
Multifocal Optical Coherence MicroscopeR21RR025788 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YAO, XINCHENG · 2009 to 2010
$517k
Angle-resolved polarization signal imaging of early receptor potentialR21EB012264 · NIBIB · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YAO, XINCHENG · 2011 to 2012
$381k
NCRR NIH HHS R21 RR025788NIBIB NIH HHS R21 EB012264NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P60 DK079626
6 · The paper itself

Abstract

We demonstrate intrinsic optical signal (IOS) imaging of intact rat islet, which consists of many endocrine cells working together. A near-infrared digital microscope was employed for optical monitoring of islet activities evoked by glucose stimulation. Dynamic NIR images revealed transient IOS responses in the islet activated by low-dose (2.75mM) and high-dose (5.5mM) glucose stimuli. Comparative experiments and quantitative analysis indicated that both glucose metabolism and calcium/insulin dynamics might contribute to the observed IOS responses. Further investigation of the IOS imaging technology may provide a high resolution method for

Indexed as

functional imagingglucose stimulationintrinsic optical signalrat islet

Identifiers

PMID24363496
PMCPMC3867949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.