Evidence map›Paper›PMID 24363466›Full record

ArticleTetrahedron letters2013

Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.

Ginamarie Debevec, Wenteng Chen, Yongping Yu, Richard A Houghten, Marc A Giulianotti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library.Combinatorial chemistry & high throughput screening · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ginamarie DebevecTorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987.
Wenteng ChenTorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987 ; Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
Yongping YuInstitute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
Richard A HoughtenTorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987.
Marc A GiulianottiTorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987.

Funding

High throughput in vivo screening: translational generation of novel analgesicsR01DA031370 · NIDA · TORREY PINES INST FOR MOLECULAR STUDIES · PI HOUGHTEN, RICHARD ALLEN · 2011 to 2015
$2.2M
NIDA NIH HHS R01 DA031370
6 · The paper itself

Abstract

A libraries from libraries approach is described for the synthesis of five different sulfonamide linked scaffolds. Four of the scaffolds are sulfonamides linked to heterocycles; piperazine, thiourea, cyclic guanidine, and dimethyl cyclic guanidine. The fifth scaffold is a polyamine linked sulfonamide. Three different diversity positions were effectively incorporated into each scaffold providing a number of different compounds with good yields and purity.

Indexed as

guanidinelibraries from librariespiperazinepositional scanningsulfonamideurea

Identifiers

PMID24363466
PMCPMC3867824

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.