ReviewEpidemiologic reviews2014
Epidemiologic tools to study the influence of environmental factors on fecundity and pregnancy-related outcomes.
Review in Epidemiologic reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis.Human reproduction update · 2020Pooled it
- Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis.Environmental health perspectives · 2016Pooled it
- Extreme temperature events exposure and risks of stillbirths: nationwide large birth cohort study in China.Environment international · 2025Article
- Does Older Age Modify Associations between Endocrine Disrupting Chemicals and Fecundability?International journal of environmental research and public health · 2022Article
- A multistate competing risks framework for preconception prediction of pregnancy outcomes.BMC medical research methodology · 2022Article
- Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis.Human reproduction open · 2022Review
- Folic Acid Supplementation and the Association between Maternal Airborne Particulate Matter Exposure and Preterm Delivery: A National Birth Cohort Study in China.Environmental health perspectives · 2020Article
- Assessment of environmental knowledge and needs among assisted reproductive technology professionals.Journal of assisted reproduction and genetics · 2020Article
- Endocrine-disrupting chemicals: implications for human health.The lancet. Diabetes & endocrinology · 2020Review
- Use of Electronic Nicotine Delivery Systems (ENDS) by pregnant women I: Risk of small-for-gestational-age birth.Tobacco induced diseases · 2019Article
- Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores.Environmental health : a global access science source · 2018Article
- Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China.JAMA pediatrics · 2018Article
- Trends in Fetal Growth Between 2000 to 2014 in Singleton Live Births from Israel.Scientific reports · 2018Article
- Importance of metabolomics analyses of maternal parameters and their influence on fetal growth.Experimental and therapeutic medicine · 2017Article
- Application of space-time disease clustering by administrative databases in Italy: Adverse Reproductive Outcomes (AROs) and residential exposure.Population health metrics · 2015Article
- Epigenomic programing: a future way to health?Microbial ecology in health and disease · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse pregnancy outcomes entail a large health burden for the mother and offspring; a part of it might be avoided by better understanding the role of environmental factors in their etiology. Our aims were to review the assessment tools to characterize fecundity troubles and pregnancy-related outcomes in human populations and their sensitivity to environmental factors. For each outcome, we reviewed the possible study designs, main sources of bias, and their suggested cures. In terms of study design, for most pregnancy outcomes, cohorts with recruitment early during or even before pregnancy allow efficient characterization of pregnancy-related events, time-varying confounders, and in utero exposures that may impact birth outcomes and child health. Studies on congenital anomalies require specific designs, assessment of anomalies in medical pregnancy terminations, and, for congenital anomalies diagnosed postnatally, follow-up during several months after birth. Statistical analyses should take into account environmental exposures during the relevant time windows; survival models are an appropriate approach for fecundity, fetal loss, and gestational duration/preterm delivery. Analysis of gestational duration could distinguish pregnancies according to delivery induction (and possibly pregnancy-related conditions). In conclusion, careful design and analysis are required to better characterize environmental effects on human reproduction.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.