ArticleAmerican journal of physiology. Heart and circulatory physiology2014
Cardiac function of the naked mole-rat: ecophysiological responses to working underground.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Cardiometabolic adaptations in the cave nectar bat Eonycteris spelaea.Communications biology · 2026Article
- Impact of acute and chronic hypoxia on the heme oxygenase/carbon monoxide pathway in naked mole-rats (Heterocephalus glaber).The Journal of experimental biology · 2025Article
- Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.Nature communications · 2024Article
- Housing and Husbandry Alternatives for Naked Mole Rat Colonies Used in Research Settings.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Fuel source shift or cost reduction: Context-dependent adaptation strategies in closely relatedZoological research · 2022Article
- Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life.GeroScience · 2022Article
- Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat.BMC biology · 2022Article
- The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.Biological reviews of the Cambridge Philosophical Society · 2022Review
- The hypoxia adaptation of small mammals to plateau and underground burrow conditions.Animal models and experimental medicine · 2021Review
- The Idiosyncratic Physiological Traits of the Naked Mole-Rat; a Resilient Animal Model of Aging, Longevity, and Healthspan.Advances in experimental medicine and biology · 2021Review
- The variable heartbeat of Japanese moles (Mogera spp.).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Transcriptome sequencing of Eospalax fontanierii to determine hypoxia regulation of cardiac fibrinogen.Molecular biology reports · 2019Article
- Cardiac metabolomic profile of the naked mole-rat-glycogen to the rescue.Biology letters · 2019Article
- Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency.PLoS genetics · 2019Article
- Article
- Comparison of Biomechanical Properties and Microstructure of Trabeculae Carneae, Papillary Muscles, and Myocardium in the Human Heart.Journal of biomechanical engineering · 2019Article
- A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.GeroScience · 2018Article
- The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.Pflugers Archiv : European journal of physiology · 2017Article
- Biomechanics of Cardiac Function.Comprehensive Physiology · 2015Review
- Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction.Journal of molecular and cellular cardiology · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The naked mole-rat (NMR) is a strictly subterranean rodent with a low resting metabolic rate. Nevertheless, it can greatly increase its metabolic activity to meet the high energetic demands associated with digging through compacted soils in its xeric natural habitat where food is patchily distributed. We hypothesized that the NMR heart would naturally have low basal function and exhibit a large cardiac reserve, thereby mirroring the species' low basal metabolism and large metabolic scope. Echocardiography showed that young (2-4 yr old) healthy NMRs have low fractional shortening (28 ± 2%), ejection fraction (43 ± 2%), and cardiac output (6.5 ± 0.4 ml/min), indicating low basal cardiac function. Histology revealed large NMR cardiomyocyte cross-sectional area (216 ± 10 μm(2)) and cardiac collagen deposition of 2.2 ± 0.4%. Neither of these histomorphometric traits was considered pathological, since biaxial tensile testing showed no increase in passive ventricular stiffness. NMR cardiomyocyte fibers showed a low degree of rotation, contributing to the observed low NMR cardiac contractility. Interestingly, when the exercise mimetic dobutamine (3 μg/g ip) was administered, NMRs showed pronounced increases in fractional shortening, ejection fraction, cardiac output, and stroke volume, indicating an increased cardiac reserve. The relatively low basal cardiac function and enhanced cardiac reserve of NMRs are likely to be ecophysiological adaptations to life in an energetically taxing environment.
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