ReviewCurrent psychiatry reports2014
The hypocretin system and psychiatric disorders.
Review in Current psychiatry reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Plasma Orexin-A Levels in Patients With Schizophrenia: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Narcolepsy and psychosis: A systematic review.Acta psychiatrica Scandinavica · 2021Pooled it
- Psychiatric comorbidity in Danish patients with narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a case-control study.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Jingqianshu granules mitigates premenstrual depression by regulating orexin signaling.Frontiers in pharmacology · 2024Article
- Does EGFR Signaling Mediate Orexin System Activity in Sleep Initiation?International journal of molecular sciences · 2023Review
- The potential role of the orexin system in premenstrual syndrome.Frontiers in endocrinology · 2023Review
- Subjective sleep disorders and daytime sleepiness in patients with restrictive type anorexia nervosa and effects on quality of life: a case-control study.Sleep and biological rhythms · 2022Article
- Neuropsychiatric Correlates of Narcolepsy.Current psychiatry reports · 2020Review
- Autism Spectrum Disorder and Narcolepsy: A Possible Connection That Deserves to Be Investigated.Frontiers in psychiatry · 2020Article
- Comorbidity of Narcolepsy and Psychotic Disorders: A Nationwide Population-Based Study in Taiwan.Frontiers in psychiatry · 2020Article
- Orexinergic modulation of serotonin neurons in the dorsal raphe of a diurnal rodent, Arvicanthis niloticus.Hormones and behavior · 2019Article
- Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy.Drug design, development and therapy · 2018Review
- Psychosocial Profile and Quality of Life in Children With Type 1 Narcolepsy: A Case-Control Study.Sleep · 2016Article
- Treatment Options for Narcolepsy.CNS drugs · 2016Review
- Psychosis in patients with narcolepsy as an adverse effect of sodium oxybate.Frontiers in neurology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypocretin system is constituted by a small group of hypothalamic neurons with widespread connections within the entire central nervous system producing two neuropeptides involved in several key physiological functions such as the regulation of sleep and wakefulness, motor control, autonomic functions, metabolism, feeding behavior, and reward. Narcolepsy with cataplexy is a neurological disorder regarded as a disease model for the selective hypocretin system damage, and also shares several psychopatological traits and comorbidities with psychiatric disorders. We reviewed the available literature on the involvement of the hypocretin system in psychiatric nosography. Different evidences such as cerebrospinal hypocretin-1 levels, genetic polymorphisms of the neuropeptides or their receptors, response to treatments, clinical, experimental and functional data directly or indirectly linked the hypocretin system to schizophrenia, mood, anxiety and eating disorders, as well as to addiction. Future genetic and pharmacological studies will disentangle the hypocretin system role in the field of psychiatry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.