ArticleAmerican journal of Alzheimer's disease and other dementias2013
Stability of clinical etiologic diagnosis in dementia and mild cognitive impairment: results from a multicenter longitudinal database.
Article in American journal of Alzheimer's disease and other dementias, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Diagnostic Stability of ICD/DSM First Episode Psychosis Diagnoses: Meta-analysis.Schizophrenia bulletin · 2016Pooled it
- Diagnostic Reversion in Dementia Care: A Real-World Analysis of Mild Cognitive Impairment Diagnoses Following Dementia in a Large Electronic Medical Record System.medRxiv : the preprint server for health sciences · 2025Article
- Clinical outcomes up to 9 years after [Alzheimer's research & therapy · 2023Article
- The evolution of diagnosis from symptom onset to death in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) compared to Parkinson's disease (PD).Journal of neurology · 2023Article
- Development and Validation of Predictive Model for a Diagnosis of First Episode Psychosis Using the Multinational EU-GEI Case-control Study and Modern Statistical Learning Methods.Schizophrenia bulletin open · 2023Article
- Memory improvement in African Americans with amnestic mild cognitive impairment.International journal of geriatric psychiatry · 2019Article
- The Contribution of Supplementary Tests in the Differential Diagnosis of Dementia.American journal of Alzheimer's disease and other dementias · 2018Article
- Risk Factors for the Progression of Mild Cognitive Impairment in Different Types of Neurodegenerative Disorders.Behavioural neurology · 2018Observational
- Stability of mild cognitive impairment in newly diagnosed Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2017Article
- Treatment Patterns with Antidementia Drugs in the United States: Medicare Cohort Study.Journal of the American Geriatrics Society · 2016Article
- Clinical workout for the early detection of cognitive decline and dementia.European journal of clinical nutrition · 2014Review
- Application of Optical Coherence Tomography in the Detection and Classification of Cognitive Decline.Journal of current glaucoma practiceReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Many new therapies for dementia target a specific pathologic process and must be applied early. Selection of specific therapy is based on the clinical etiologic diagnosis. We sought to determine the stability of the clinical etiologic diagnosis over time and to identify factors associated with instability. We identified 4141 patients with dementia or mild cognitive impairment who made at least 2 visits approximately a year apart to a dementia research center, receiving a clinical etiologic diagnosis on each visit. We assessed concordance of etiologic diagnoses across visits, κ-statistics, and transition probabilities among diagnoses. The primary clinical etiologic diagnosis remained stable for 91% of patients but with a net shift toward dementia with Lewy bodies and Alzheimer's disease. Lower diagnostic stability was significantly associated with older age, nonwhite race, milder disease at presentation, more underlying conditions contributing to cognitive decline, lack of a consistent spouse/partner informant, and being evaluated by different clinicians on different visits. Multistate Markov modeling generally confirmed these associations. Clinical etiologic diagnoses were generally stable. However, several readily ascertained characteristics were associated with higher instability. These associations may be useful to clinicians for anticipating when an etiologic diagnosis may be more prone to future change.
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Registered trials
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