ArticleJournal of biomedical optics2013
Design and characterization of an optimized simultaneous color and near-infrared fluorescence rigid endoscopic imaging system.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- New Concept of Intraoperative Fluorescence Diagnostics for Photodynamic Dosimetry of Tumors Using Chlorin-Based Photosensitizers.Biosensors · 2026Article
- Quantitative Fluorescence Imaging of Chemophototherapy Drug Pharmacokinetics Using Laparoscopic SFDI.International journal of molecular sciences · 2025Article
- Ultra-miniature dual-wavelength spatial frequency domain imaging for micro-endoscopy.Journal of biomedical optics · 2024Article
- Application of near-infrared fluorescence imaging in theranostics of gastrointestinal tumors.Gastroenterology report · 2023Review
- A review of the application of machine learning in molecular imaging.Annals of translational medicine · 2021Review
- Enhancement of signal-to-noise ratio for fluorescence endoscope image based on fast digital lock-in algorithm.Royal Society open science · 2021Article
- Multicolor fluorescence imaging using a single RGB-IR CMOS sensor for cancer detection with smURFP-labeled probiotics.Biomedical optics express · 2020Article
- Rapid pathology of lumpectomy margins with open-top light-sheet (OTLS) microscopy.Biomedical optics express · 2019Article
- Real-Time Imaging of Brain Tumor for Image-Guided Surgery.Advanced healthcare materials · 2018Review
- Real-time endoscopic optical properties imaging.Biomedical optics express · 2017Article
- Electrically tunable fluidic lens imaging system for laparoscopic fluorescence-guided surgery.Biomedical optics express · 2017Article
- Intraoperative Near-Infrared Fluorescence Imaging of Thymus in Preclinical Models.The Annals of thoracic surgery · 2017Article
- In vivo fluorescence imaging of hepatocellular carcinoma xenograft using near-infrared labeled epidermal growth factor receptor (EGFR) peptide.Biomedical optics express · 2016Article
- Real-Time Visualization of Tissue Surface Biochemical Features Derived From Fluorescence Lifetime Measurements.IEEE transactions on medical imaging · 2016Article
- Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery.Theranostics · 2015Article
- Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system.Journal of biomedical optics · 2015Article
- Single camera imaging system for color and near-infrared fluorescence image guided surgery.Biomedical optics express · 2014Article
- Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology.Theranostics · 2014Review
- Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging.Journal of biomedical optics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 3 countries.
Funding
Abstract
We report the design, characterization, and validation of an optimized simultaneous color and near-infrared (NIR) fluorescence rigid endoscopic imaging system for minimally invasive surgery. This system is optimized for illumination and collection of NIR wavelengths allowing the simultaneous acquisition of both color and NIR fluorescence at frame rates higher than 6.8 fps with high sensitivity. The system employs a custom 10-mm diameter rigid endoscope optimized for NIR transmission. A dual-channel light source compatible with the constraints of an endoscope was built and includes a plasma source for white light illumination and NIR laser diodes for fluorescence excitation. A prism-based 2-CCD camera was customized for simultaneous color and NIR detection with a highly efficient filtration scheme for fluorescence imaging of both 700- and 800-nm emission dyes. The performance characterization studies indicate that the endoscope can efficiently detect fluorescence signal from both indocyanine green and methylene blue in dimethyl sulfoxide at the concentrations of 100 to 185 nM depending on the background optical properties. Finally, we performed the validation of this imaging system in vivo during a minimally invasive procedure for thoracic sentinel lymph node mapping in a porcine model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.