Evidence map›Paper›PMID 24362621›Full record

ArticleJournal of gastrointestinal cancer2014

Modified GTX as second-line therapy for advanced pancreatic adenocarcinoma.

Hana Ajouz, Deborah Mukherji, Ali Haydar, Ahmad Sharif Yakan, Ahmad Saleh, Elias Elias, Sally Temraz, Walid Faraj, Mohammad Khalife, Ali Shamseddine

Abstract read
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Article in Journal of gastrointestinal cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hana AjouzDivision of Hematology and Oncology, American University of Beirut Medical Center, Beirut, Lebanon, hma40@aub.edu.lb.
Deborah Mukherji
Ali Haydar
Ahmad Sharif Yakan
Ahmad Saleh
Elias Elias
Sally Temraz
Walid Faraj
Mohammad Khalife
Ali Shamseddine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvanced pancreatic cancer remains a lethal disease with no standard treatment beyond first-line palliative chemotherapy. Gemcitabine, docetaxel, and capecitabine (GTX) is a regimen that has come into use for advanced pancreatic cancer despite a paucity of randomized data.

methodsWe have used a modified schedule of this regimen in the second-line setting aimed at biomodulating the activity of capecitabine by both docetaxel and gemcitabine. This report describes our experience with the use of modified GTX in nine patients with advanced pancreatic cancer as second-line chemotherapy.

conclusionIn our series, the median overall survival was 8 months (range 5.2-10.8). Prospective studies of this regimen in the second-line setting are warranted.

Indexed as

Salvage TherapyAdenocarcinomaAgedAntineoplastic Combined Chemotherapy ProtocolsCapecitabineDeoxycytidineDocetaxelFemaleFluorouracilFollow-Up StudiesGemcitabineHumansMaleMiddle AgedNeoplasm StagingPancreatic NeoplasmsCapecitabineDeoxycytidineDocetaxelFluorouracilGemcitabineTaxoids

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.