ArticleNature reviews. Drug discovery2014
A new roadmap for drug development for Alzheimer's disease.
Registry-linked trialAbstract readLetterComment
In one paragraph
Article in Nature reviews. Drug discovery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06774261 (A Phase 1b Dose Range Finding Study of Phenserine Compared to Donepezil in Participants With Early or Mild Alzheimer's Disease), which is not on this map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1b Dose Range Finding Study of Phenserine Compared to Donepezil in Participants With Early or Mild Alzheimer's Disease
Who cites it
32 citing papers in PubMed.
- Development of quantitative detection methods for four Alzheimer's disease specific biomarker panels using electrochemical immunosensors based on enzyme immunoassay.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- GS-SMD server for steered molecular dynamics of peptide substrates in the active site of the γ-secretase complex.Nucleic acids research · 2023Article
- Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study.Molecules (Basel, Switzerland) · 2022Article
- Review
- The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex.Biomolecules · 2021Article
- Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).International journal of molecular sciences · 2021Article
- Phytochemical Analysis and Evaluation of Biological Activity ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Subjective Cognitive Decline and Related Cognitive Deficits.Frontiers in neurology · 2020Review
- 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells.ACS chemical neuroscience · 2019Article
- Neurotheranostics as personalized medicines.Advanced drug delivery reviews · 2019Review
- Pre-Clinical Safety and Efficacy Evaluation of Amytrap, a Novel Therapeutic to Treat Alzheimer's Disease.Journal of Alzheimer's disease reports · 2019Article
- 'Amytrapper', a Novel Immobilized Sepharose API Matrix, Removes Amyloid-β from CirculationJournal of Alzheimer's disease reports · 2019Article
- Evaluation of Functional Decline in Alzheimer's Dementia Using 3D Deep Learning and Group ICA for rs-fMRI Measurements.Frontiers in aging neuroscience · 2019Article
- Can We Prevent Dementia and Not Prevent Neurons from Dying?Journal of Alzheimer's disease : JAD · 2019Article
- Exploring the Multi-Target Neuroprotective Chemical Space of Benzofuran Scaffolds: A New Strategy in Drug Development for Alzheimer's Disease.Frontiers in pharmacology · 2019Review
- Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease.RSC advances · 2018Review
- Does traumatic brain injury hold the key to the Alzheimer's disease puzzle?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Review
- Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.ACS medicinal chemistry letters · 2016Article
- Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug development.Journal of neuroscience methods · 2016Article
Corrections and comments
- Comment on
Authors and funding
5 authors.
Robert E BeckerAristea Translational Medicine, 5011 Mountain View Road #63, Carrabassett Valley, Maine O4947, USA, and a Clinical Consultant in the Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Nigel H GreigDrug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore Maryland 21224, USA.
Ezio GiacobiniDepartment of Internal Medicine, Rehabilitation, and Geriatrics, University of Geneva, Medical School, University Hospitals of Geneva, Thonex-Geneva, Switzerland.
Lon S SchneiderDepartments of Psychiatry, Neurology, and Gerontology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Luigi FerrucciIntramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Funding
The Baltimore Longitudinal Study Of AgingZIAAG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI SIMONSICK, ELEANOR MARIE · 2009 to 2025
$116.9MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0MDesign And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)ZIAAG000311 · NIA · NATIONAL INSTITUTE ON AGING · PI GREIG, NIGEL H. · 2009 to 2025
$16.0MTHE BALTIMORE LONGITUDINAL STUDY OF HUMAN AGINGZ01AG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 1985 to 2008
$11.4MIntramural NIH HHS Z01 AG000015NIA NIH HHS P50 AG005142
Abstract
PubMed holds no abstract for this paper.
Indexed as
Alzheimer DiseaseClinical Trials as TopicHumans
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06774261ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.