ArticleThe Journal of biological chemistry2014
Structure of Clostridium difficile PilJ exhibits unprecedented divergence from known type IV pilins.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Insight into the relationship between type IV pilus function and biofilm formation.Biochemical Society transactions · 2026Review
- Type IV pili ofEcoSal Plus · 2024Review
- Clostridioides difficile Biofilm.Advances in experimental medicine and biology · 2024Article
- Oligomerization and Adjuvant Activity of Peptides Derived from the VirB4-like ATPase ofBiomolecules · 2023Article
- Phylogenetic analysis of the bacterial Pro-Pro-endopeptidase domain reveals a diverse family including secreted and membrane anchored proteins.Current research in microbial sciences · 2021Review
- VirB4- and VirD4-Like ATPases, Components of a Putative Type 4C Secretion System in Clostridioides difficile.Journal of bacteriology · 2021Article
- Caldicellulosiruptor bescii Adheres to Polysaccharides via a Type IV Pilin-Dependent Mechanism.Applied and environmental microbiology · 2020Article
- A practical overview of molecular replacement: Clostridioides difficile PilA1, a difficult case study.Acta crystallographica. Section D, Structural biology · 2020Article
- Monoderm bacteria: the new frontier for type IV pilus biology.Molecular microbiology · 2019Review
- Protein Nanotubes: From Bionanotech towards Medical Applications.Biomedicines · 2019Review
- The Dynamic Structures of the Type IV Pilus.Microbiology spectrum · 2019Review
- The structure of PilA fromThe Journal of biological chemistry · 2019Article
- Gram-Positive Type IV Pili and Competence.Microbiology spectrum · 2019Article
- Type IV Pili Promote Clostridium difficile Adherence and Persistence in a Mouse Model of Infection.Infection and immunity · 2018Article
- Biofilm Formation by Clostridium ljungdahlii Is Induced by Sodium Chloride Stress: Experimental Evaluation and Transcriptome Analysis.PloS one · 2017Article
- Motility and adhesion through type IV pili in Gram-positive bacteria.Biochemical Society transactions · 2016Review
- Structural Diversity in the Type IV Pili of Multidrug-resistant Acinetobacter.The Journal of biological chemistry · 2016Article
- Article
- Type IV pili promote early biofilm formation by Clostridium difficile.Pathogens and disease · 2016Article
- Regulation of Type IV Pili Contributes to Surface Behaviors of Historical and Epidemic Strains of Clostridium difficile.Journal of bacteriology · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Type IV pili are produced by many pathogenic Gram-negative bacteria and are important for processes as diverse as twitching motility, cellular adhesion, and colonization. Recently, there has been an increased appreciation of the ability of Gram-positive species, including Clostridium difficile, to produce Type IV pili. Here we report the first three-dimensional structure of a Gram-positive Type IV pilin, PilJ, demonstrate its incorporation into Type IV pili, and offer insights into how the Type IV pili of C. difficile may assemble and function. PilJ has several unique structural features, including a dual-pilin fold and the incorporation of a structural zinc ion. We show that PilJ is incorporated into Type IV pili in C. difficile and present a model in which the incorporation of PilJ into pili exposes the C-terminal domain of PilJ to create a novel interaction surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.