ArticleProceedings of the National Academy of Sciences of the United States of America1987
Expression of the proopiomelanocortin gene is developmentally regulated and affected by germ cells in the male mouse reproductive system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 56 citations in OpenAlex.
- POMC: The Physiological Power of Hormone Processing.Physiological reviews · 2018Review
- Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis.The EMBO journal · 1993Article
- List of cloned mouse genes with unique expression patterns during spermatogenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Pituitary-like proopiomelanocortin transcripts in human Leydig cell tumors.The Journal of clinical investigation · 1990Article
- Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Expression of a testis-specific hsp70 gene-related RNA in defined stages of rat seminiferous epithelium.The Journal of cell biology · 1988Article
- Expression of cellular protooncogenes in the mouse male germ line: a distinctive 2.4-kilobase pim-1 transcript is expressed in haploid postmeiotic cells.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
- Differential expression of opioid peptide genes by testicular germ cells and somatic cells.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
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Authors and funding
2 authors.
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Abstract
Proopiomelanocortin (POMC), a major pituitary product, is also present in the adult mouse testis. We have shown previously that POMC mRNAs are most abundant in a subpopulation of Leydig cells associated with tubules in specific stages of the cycle of the seminiferous epithelium. In the present study, we examined the expression of the gene encoding POMC during testicular development and in other tissues of the male reproductive system. We also analyzed the effects of cellular interactions on POMC gene expression in the testis. Blot-hybridization analysis revealed that POMC transcripts of approximately equal to 800 nucleotides were present in enriched populations of meiotic prophase spermatocytes and in caput epididymis but were absent in cauda epididymis and vas deferens. POMC transcripts were present in fetal testis (day 17 of gestation to newborn), could not be detected in prepuberal testis (days 7-8 postpartum), but reappeared in the adult testis. No difference in the size or abundance of POMC transcripts was seen in testes from mouse mutant strains in which spermatogenesis is arrested in early spermiogenesis. In contrast, POMC transcripts were virtually undetectable in testes that are devoid of germ cells. These results emphasize the importance of interactions between germ cells and interstitial cells and the regulation of the POMC gene in the mammalian testis.
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