Evidence map›Paper›PMID 24361967›Full record

ReviewNeuroscience and biobehavioral reviews2014

Developmental pathways to autism: a review of prospective studies of infants at risk.

Emily J H Jones, Teodora Gliga, Rachael Bedford, Tony Charman, Mark H Johnson

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 255 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
255citing papers in PubMed, 5 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

255 citing papers in PubMed, 5 syntheses or guidelines pooled it, 601 citations in OpenAlex.

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195 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Emily J H JonesCentre for Brain and Cognitive Development, Birkbeck College, University of London, UK. Electronic address: e.jones@bbk.ac.uk.
Teodora GligaCentre for Brain and Cognitive Development, Birkbeck College, University of London, UK.
Rachael BedfordKing's College London, Institute of Psychiatry, Department of Biostatistics, UK.
Tony CharmanKing's College London, Institute of Psychiatry, Department of Psychology, UK.
Mark H JohnsonCentre for Brain and Cognitive Development, Birkbeck College, University of London, UK.
Birkbeck, University of London · GBKing's College London · GB

Funding

Medical Research Council G0701484Medical Research Council MR/K021389/1
6 · The paper itself

Abstract

Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterized by impairments in social interaction and communication, and the presence of restrictive and repetitive behaviors. Symptoms of ASD likely emerge from a complex interaction between pre-existing neurodevelopmental vulnerabilities and the child's environment, modified by compensatory skills and protective factors. Prospective studies of infants at high familial risk for ASD (who have an older sibling with a diagnosis) are beginning to characterize these developmental pathways to the emergence of clinical symptoms. Here, we review the range of behavioral and neurocognitive markers for later ASD that have been identified in high-risk infants in the first years of life. We discuss theoretical implications of emerging patterns, and identify key directions for future work, including potential resolutions to several methodological challenges for the field. Mapping how ASD unfolds from birth is critical to our understanding of the developmental mechanisms underlying this disorder. A more nuanced understanding of developmental pathways to ASD will help us not only to identify children who need early intervention, but also to improve the range of interventions available to them.

Indexed as

Child DevelopmentAutistic DisorderBrainFamily HealthHumansInfantProspective StudiesRisk FactorsASDAutismCausal pathDevelopmental mechanismsHigh-riskInfant sibling

Identifiers

PMID24361967
PMCPMC3969297
OpenAlexW2062328738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.