ArticleToxicological sciences : an official journal of the Society of Toxicology2014
Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Epigenomic mechanisms of dietary prescriptions for obesity therapy.Epigenomics · 2025Review
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice.International journal of molecular sciences · 2023Article
- The obesogenic side of Genistein.Frontiers in endocrinology · 2023Review
- Early Postnatal Genistein Administration Affects Mice Metabolism and Reproduction in a Sexually Dimorphic Way.Metabolites · 2021Article
- Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract.Frontiers in physiology · 2021Review
- Genistein inhibits proliferation and induces senescence in neonatal mouse pituitary gland explant cultures.Toxicology · 2019Article
- Put "gender glasses" on the effects of phenolic compounds on cardiovascular function and diseases.European journal of nutrition · 2018Review
- Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior-An overview.Hormones and behavior · 2018Review
- Neonatal Genistein Exposure and Glucocorticoid Signaling in the Adult Mouse Uterus.Environmental health perspectives · 2018Article
- Epigenetic Mechanisms Link Maternal Diets and Gut Microbiome to Obesity in the Offspring.Frontiers in genetics · 2018Review
- Metabolism Disrupting Chemicals and Alteration of Neuroendocrine Circuits Controlling Food Intake and Energy Metabolism.Frontiers in endocrinology · 2018Review
- Dietary soy isoflavones during pregnancy suppressed the immune function in male offspring albino rats.Toxicology reports · 2018Article
- Soy Formula and Epigenetic Modifications: Analysis of Vaginal Epithelial Cells from Infant Girls in the IFED Study.Environmental health perspectives · 2017Article
- Bisphenol-A and metabolic diseases: epigenetic, developmental and transgenerational basis.Environmental epigenetics · 2016Review
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016Article
- Endocrine Aspects of Environmental "Obesogen" Pollutants.International journal of environmental research and public health · 2016Review
- In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge.The Journal of nutritional biochemistry · 2015Article
- The Role of Epigenetics in the Latent Effects of Early Life Exposure to Obesogenic Endocrine Disrupting Chemicals.Endocrinology · 2015Review
- Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis.Toxicology and applied pharmacology · 2015Article
- Obesity and diabetes: from genetics to epigenetics.Molecular biology reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Genistein (Gen), the primary isoflavone in soy, has been shown to adversely affect various endocrine-mediated endpoints in rodents and humans. Soy formula intake by human infants has been associated with early age at menarche and decreased female-typical behavior in girls. Adipose deposition and expansion are also hormonally regulated and Gen has been shown to alter these processes. However, little is known about the impact of early-life soy intake on metabolic homeostasis in adulthood. The current study examined the impact of early-life Gen exposure on adulthood body composition (by magnetic resonance imaging) and the molecular signals mediating adipose expansion. From postnatal day (PND) 1 to 22, rat pups were daily orally dosed with 50mg/kg Gen to mimic blood Gen levels in human infants fed soy formula. Female but not male Gen-exposed rats had increased fat/lean mass ratio, fat mass, adipocyte size and number, and decreased muscle fiber perimeter. PND22 Gen-exposed females, but not males, had increased expression of adipogenic factors, including CCAAT/enhancer binding protein alpha (Cebpα), CCAAT/enhancer binding protein beta (Cebpβ), and peroxisome proliferator-activated receptor gamma (Pparγ). Furthermore, Wingless-related MMTV integration site 10b (Wnt10b), a critical regulator of adipogenic cell fate determination, was hypermethylated and had decreased expression in adipose of PND22 Gen-exposed females. These data suggest that developmental Gen exposure in rats has gender-specific effects on adiposity that closely parallel the effects of a postweaning high-fat diet and underscore the importance of considering timing of exposure and gender when establishing safety recommendations for early-life dietary Gen intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.