ArticleJournal of cardiac failure2014
Lack of persistence of influenza vaccine antibody titers in patients with heart failure.
Article in Journal of cardiac failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02787044 (INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The benefits of influenza vaccination in patients with cardiovascular disease: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- High-dose vs. standard-dose inactivated influenza vaccine and cardiovascular outcomes in persons with or without pre-existing atherosclerotic cardiovascular disease: the DANFLU-2 trial.European heart journal · 2025Trial
- Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1-nCoV-19 Vaccine in Hemodialysis Patients.The Kaohsiung journal of medical sciences · 2026Article
- Impaired SARS-CoV-2 mRNA Vaccine Antibody Response in Chronic Medical Conditions: A Real-World Analysis.Chest · 2022Article
- T Cell Response to Influenza Vaccination Remains Intact in Adults with Congenital Heart Disease Who Underwent Early Thymectomy.International journal of cardiology. Congenital heart disease · 2022Article
- Heart failure among patients admitted with Influenza. The influenza subtypes, seasonality and mortality: A case series.Journal of family medicine and primary care · 2021Article
- Genetic Analyses of Common Infections in the Avon Longitudinal Study of Parents and Children Cohort.Frontiers in immunology · 2021Article
- Influenza Vaccination to Reduce Cardiovascular Morbidity and Mortality in Patients With COVID-19: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020Review
- Vaccines to Prevent Infectious Diseases in the Older Population: Immunological Challenges and Future Perspectives.Frontiers in immunology · 2020Review
- Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents.The Journal of infectious diseases · 2017Article
- Influenza infection and heart failure-vaccination may change heart failure prognosis?Heart failure reviews · 2017Review
- The Modification Effect of Influenza Vaccine on Prognostic Indicators for Cardiovascular Events after Acute Coronary Syndrome: Observations from an Influenza Vaccination Trial.Cardiology research and practice · 2016Article
- Skin immunization with influenza vaccines.Current topics in microbiology and immunology · 2015Review
- Influenza vaccination in north Indian patients with heart failure.Indian heart journalArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundPatients with heart failure (HF) have lower initial antibody responses to the influenza vaccine compared with healthy individuals. Whether antibody titers wane faster in this population remains unknown. METHODS AND
resultsWe studied 62 HF patients (18 ischemic, 44 idiopathic) and 40 healthy control subjects (HC) during the 2006-2007 and 2007-2008 influenza seasons. Antibody titers were measured before and 2-4 weeks and 11-12 months after vaccination. Serum antibody production was measured by hemagglutination inhibition assay, and antibody titers to individual vaccine viral strains between the HF and HC groups were compared after the influenza season to measure persistence of antibody response. All participants demonstrated early antibody seroprotection (titers 40 hemmaglutination inhibition units to 1 strain). Although antibody titers waned over time in both groups, titers to A/H3N2 and A/H1N1 strains decreased more in HF than in HC participants (P = .004 and P = .04, respectively). Titers to the B-type strain decreased to below seroprotective levels in both groups.
conclusionsAntibody titers to influenza A vaccine strains wane to below seroprotective levels in HF patients compared with HC, despite similar rates of initial seroprotection and seroconversion. These findings suggest that HF patients may remain at increased risk for influenza infection despite annual vaccination.
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