ArticleGenes & development2014
Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.
Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 33 citations in OpenAlex.
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- The vab-1/Eph receptor and ephrins efn-1 and efn-4 are required for C. elegans chemosensory and thermosensory circuit assembly and function.BMC neuroscience · 2025Article
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- Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors.Seminars in cell & developmental biology · 2024Review
- Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.Genetics · 2023Article
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- A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of aProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways.Nature communications · 2019Article
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Buffering and Amplifying Transcriptional Noise During Cell Fate Specification.Frontiers in genetics · 2018Review
- An atlas of Caenorhabditis elegans chemoreceptor expression.PLoS biology · 2018Article
- Mechanisms controlling diversification of olfactory sensory neuron classes.Cellular and molecular life sciences : CMLS · 2017Review
- Gap junctional signaling in pattern regulation: Physiological network connectivity instructs growth and form.Developmental neurobiology · 2017Review
- Stochastic left-right neuronal asymmetry in Caenorhabditis elegans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Heterotaxy in Caenorhabditis: widespread natural variation in left-right arrangement of the major organs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
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7 authors at 4 institutions in 3 countries.
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Abstract
Left/right asymmetric features of animals are either randomly distributed on either the left or right side within a population ("antisymmetries") or found stereotypically on one particular side of an animal ("directional asymmetries"). Both types of asymmetries can be found in nervous systems, but whether the regulatory programs that establish these asymmetries share any mechanistic features is not known. We describe here an unprecedented molecular link between these two types of asymmetries in Caenorhabditis elegans. The zinc finger transcription factor die-1 is expressed in a directionally asymmetric manner in the gustatory neuron pair ASE left (ASEL) and ASE right (ASER), while it is expressed in an antisymmetric manner in the olfactory neuron pair AWC left (AWCL) and AWC right (AWCR). Asymmetric die-1 expression is controlled in a fundamentally distinct manner in these two neuron pairs. Importantly, asymmetric die-1 expression controls the directionally asymmetric expression of gustatory receptor proteins in the ASE neurons and the antisymmetric expression of olfactory receptor proteins in the AWC neurons. These asymmetries serve to increase the ability of the animal to discriminate distinct chemosensory inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.