ArticleBone2014
The mechanical consequence of actual bone loss and simulated bone recovery in acute spinal cord injury.
Article in Bone, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Systematic Search and Modified e-Delphi Consensus for Serum Bone Biomarkers in Humans and Animal Models with SCI: Methodology.Topics in spinal cord injury rehabilitation · 2025Pooled it
- The effects of robot assisted gait training on temporal-spatial characteristics of people with spinal cord injuries: A systematic review.The journal of spinal cord medicine · 2018Pooled it
- Open-label clinical trial of alendronate after teriparatide therapy in people with spinal cord injury and low bone mineral density.Spinal cord · 2019Trial
- Bone fragility after spinal cord injury: reductions in stiffness and bone mineral at the distal femur and proximal tibia as a function of time.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Trial
- Mechanical Biomarkers in Bone Using Image-Based Finite Element Analysis.Current osteoporosis reports · 2023Review
- The Effects of Exercise and Activity-Based Physical Therapy on Bone after Spinal Cord Injury.International journal of molecular sciences · 2022Review
- Effect of External Mechanical Stimuli on Human Bone: a narrative review.Progress in biomedical engineering (Bristol, England) · 2022Article
- Functional electrical stimulation (FES)-assisted rowing combined with zoledronic acid, but not alone, preserves distal femur strength and stiffness in people with chronic spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Stiffness and Strength Predictions From Finite Element Models of the Knee are Associated with Lower-Limb Fractures After Spinal Cord Injury.Annals of biomedical engineering · 2021Article
- Analysis of the evolution of cortical and trabecular bone compartments in the proximal femur after spinal cord injury by 3D-DXA.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Observational
- Bone loss at the distal femur and proximal tibia in persons with spinal cord injury: imaging approaches, risk of fracture, and potential treatment options.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Bone Imaging and Fracture Risk after Spinal Cord Injury.Current osteoporosis reports · 2015Review
- Measurement of Bone: Diagnosis of SCI-Induced Osteoporosis and Fracture Risk Prediction.Topics in spinal cord injury rehabilitation · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionSpinal cord injury (SCI) is characterized by rapid bone loss and an increased risk of fragility fracture around regions of the knee. Our purpose was to quantify changes in torsional stiffness K and strength Tult at the proximal tibia due to actual bone loss and simulated bone recovery in acute SCI.
methodsComputed tomography scans were acquired on ten subjects with acute SCI at serial time points separated by a mean of 3.9months (range 3.0 to 4.8months). Reductions in bone mineral were quantified and a validated subject-specific finite element modeling procedure was used to predict changes in K and Tult. The modeling procedure was subsequently used to examine the effect of simulated hypothetical treatments, in which bone mineral of the proximal tibiae were restored to baseline levels, while all other parameters were held constant.
resultsDuring the acute period of SCI, subjects lost 8.3±4.9% (p<0.001) of their bone mineral density (BMD). Reductions in K (-9.9±6.5%; p=0.002) were similar in magnitude to reductions in BMD, however reductions in Tult (-15.8±13.8%; p=0.005) were some 2 times greater than the reductions in BMD. Owing to structural changes in geometry and mineral distribution, Tult was not necessarily recovered when bone mineral was restored to baseline, but was dependent upon the degree of bone loss prior to hypothetical treatments (r≥0.719; p≤0.019).
conclusionsTherapeutic interventions to halt or attenuate bone loss associated with SCI should be implemented soon after injury in an attempt to preserve mechanical integrity and prevent fracture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.