ArticleNeuroscience letters2014
Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice.
Article in Neuroscience letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Restoring GABAFrontiers in molecular neuroscience · 2024Article
- Sexual satiety modifies methamphetamine-induced locomotor and rewarding effects and dopamine-related protein levels in the striatum of male rats.Psychopharmacology · 2023Article
- A reinforcement learning model with choice traces for a progressive ratio schedule.Frontiers in behavioral neuroscience · 2023Article
- Striatal miR-183-5p inhibits methamphetamine-induced locomotion by regulating glucocorticoid receptor signaling.Frontiers in pharmacology · 2022Article
- Distinct dose-dependent effects of methamphetamine on real-time dopamine transmission in the rat nucleus accumbens and behaviors.Journal of neurochemistry · 2021Article
- Low-normal doses of methiopropamine induce aggressive behaviour in mice.Psychopharmacology · 2021Article
- Sex differences and Tat expression affect dopaminergic receptor expression and response to antioxidant treatment in methamphetamine-sensitized HIV Tat transgenic mice.Neuropharmacology · 2020Article
- Article
- HIV-1 TAT protein enhances sensitization to methamphetamine by affecting dopaminergic function.Brain, behavior, and immunity · 2017Article
- Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice.ACS chemical neuroscience · 2016Article
- An Acute Methamphetamine Injection Downregulates the Expression of Several Histone Deacetylases (HDACs) in the Mouse Nucleus Accumbens: Potential Regulatory Role of HDAC2 Expression.Neurotoxicity research · 2016Article
- Differential modulation of methamphetamine-mediated behavioral sensitization by overexpression of Mu opioid receptors in nucleus accumbens and ventral tegmental area.Psychopharmacology · 2016Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Repeated exposure to drugs of abuse produces a persistent behavioral sensitization to stimulants, which is often used to study drug-associated behavioral plasticity. Interestingly, even a single exposure to some drugs of abuse is sufficient to elicit long-lasting behavioral sensitization. However, few studies have directly compared the magnitude of sensitization between single versus repeated drug treatments. This study examined the magnitude and duration of single methamphetamine (METH) injection-induced behavioral sensitization and compared it to the more typical repeated drug injection-induced sensitization in mice. Different groups of mice were injected with METH (0.5, 1.0, 2.0mg/kg, i.p.) only once or daily for 7 consecutive days. A challenge dose of METH (1.0mg/kg, i.p.) was tested 7 days later. The time-course of a single METH injection-induced behavioral sensitization was assessed where METH (2.0mg/kg, i.p.) was injected and a challenge dose of METH (1.0mg/kg, i.p.) was tested after different drug-free periods. Single METH injection produced similar magnitude of behavioral sensitization as compared to repeated injection. Such a sensitized locomotor response peaked 8 days after METH injection and lasted for at least 21 days. This long lasting behavioral alteration induced by single METH injection suggests the value of future studies to explore the underlying neural mechanisms, particularly in comparison to those underlying repeated METH-induced sensitization.
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