Evidence map›Paper›PMID 24361109›Full record

Trial reportThe journal of pain2014

Spinal manipulative therapy-specific changes in pain sensitivity in individuals with low back pain (NCT01168999).

Joel E Bialosky, Steven Z George, Maggie E Horn, Donald D Price, Roland Staud, Michael E Robinson

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 61 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 9 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01168999 phase1 / phase2completednot on this map

The Mechanisms of Manual Therapy in the Treatment of Low Back Pain

TypeinterventionalSponsorUniversity of FloridaRan2009 to 2013Enrolled110ConditionsLow Back PainArmsspinal manipulation, sham spinal manipulation, Enhanced sham spinal manipulation
NCT02396550 nacompletednot on this mapstarted 2015, after this paper: background citation

Influence of Patient Expectations With Lateral Epicondylalgia in Applying Mobilization With Movement. Clinical Trial

TypeinterventionalSponsorUniversity of AlcalaRan2015 to 2016Enrolled66ConditionsTennis ElbowArmsPositive Expectations, Mobilization with movement
NCT04347551 nacompletednot on this mapstarted 2021, after this paper: background citation

Motor Performance of Asymptomatic and Chronic Neck Pain Participants Pre- and Post-spinal Manipulation Using an Eye and Head Movement Fitts' Task

TypeinterventionalSponsorUniversity of ManitobaRan2021 to 2021Enrolled40ConditionsChronic Neck PainArmsHigh velocity/low amplitude cervical spine manipulation
NCT04744883 early_phase1active not recruitingnot on this mapstarted 2020, after this paper: background citation

Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain

TypeinterventionalSponsorRush University Medical CenterRan2020 to 2026Enrolled140ConditionsChronic Low-back PainArmsSpinal Manipulation Therapy (SMT), Naloxone, Placebo, Mindfulness Based Stress Reduction Therapy (MT)
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 9 syntheses or guidelines pooled it, 162 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  4. Manual Therapy Effect in Placebo-Controlled Trials: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  5. Placebo effects in low back pain: A systematic review and meta-analysis of the literature.European journal of pain (London, England) · 2021 · on this map
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joel E BialoskyDepartment of Physical Therapy, Center for Pain Research and Behavioral Health, University of Florida, Gainesville, Florida. Electronic address: bialosky@phhp.ufl.edu.
Steven Z GeorgeDepartment of Physical Therapy, Center for Pain Research and Behavioral Health, University of Florida, Gainesville, Florida.
Maggie E HornDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Donald D PriceOral and Maxillofacial Surgery, Division of Neuroscience, University of Florida, Gainesville, Florida.
Roland StaudDepartment of Medicine, University of Florida, Gainesville, Florida.
Michael E RobinsonDepartment of Clinical and Health Psychology, Center for Pain Research and Behavioral Health, University of Florida, Gainesville, Florida.
University of Florida · USUniversity of Florida Health · US

Funding

Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Central Mechanisms of Body Based Intervention for Musculoskeletal Low Back PainR01AT006334 · NCCIH · UNIVERSITY OF FLORIDA · PI BISHOP, MARK D. · 2011 to 2015
$1.6M
NCCIH NIH HHS 5R01AT006334NCCIH NIH HHS R01 AT006334NICHD NIH HHS 5K12HD055929-02NICHD NIH HHS K12 HD055929
6 · The paper itself

Abstract

unlabelledSpinal manipulative therapy (SMT) is effective for some individuals experiencing low back pain; however, the mechanisms are not established regarding the role of placebo. SMT is associated with changes in pain sensitivity, suggesting related altered central nervous system response or processing of afferent nociceptive input. Placebo is also associated with changes in pain sensitivity, and the efficacy of SMT for changes in pain sensitivity beyond placebo has not been adequately considered. We randomly assigned 110 participants with low back pain to receive SMT, placebo SMT, placebo SMT with the instructional set "The manual therapy technique you will receive has been shown to significantly reduce low back pain in some people," or no intervention. Participants receiving the SMT and placebo SMT received their assigned intervention 6 times over 2 weeks. Pain sensitivity was assessed prior to and immediately following the assigned intervention during the first session. Clinical outcomes were assessed at baseline and following 2 weeks of participation in the study. Immediate attenuation of suprathreshold heat response was greatest following SMT (P = .05, partial η(2) = .07). Group-dependent differences were not observed for changes in pain intensity and disability at 2 weeks. Participant satisfaction was greatest following the enhanced placebo SMT. This study was registered at www.clinicaltrials.gov under the identifier NCT01168999. PERSPECTIVE: The results of this study indicate attenuation of pain sensitivity is greater in response to SMT than the expectation of receiving an SMT. These findings suggest a potential mechanism of SMT related to lessening of central sensitization and may indicate a preclinical effect beyond the expectations of receiving SMT.

Indexed as

Musculoskeletal ManipulationsAdultCentral Nervous System SensitizationDisability EvaluationFemaleHot TemperatureHumansLow Back PainMalePain MeasurementPain ThresholdPatient SatisfactionSurveys and QuestionnairesTime FactorsTreatment OutcomeCentral sensitizationlow back painmanual therapyplacebospinal manipulation

Identifiers

PMID24361109
PMCPMC3946602
OpenAlexW1980898866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.