ArticleChemistry & biology2014
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation.
Article in Chemistry & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Novel insights into gut microbiota alterations in major depressive disorder with suicidal ideation: a metagenomic analysis.Frontiers in microbiology · 2026Article
- Genomic context analysis enables the discovery of an unusual NAD-dependent racemase in phosphonate catabolism.The FEBS journal · 2025Article
- Enhanced Natural Attenuation of Gasoline Contaminants in Groundwater: Applications and Challenges of Nitrate-Stimulating Substances.Microorganisms · 2025Article
- Zinc ion increases the effectiveness of phosphorus in agricultural soils through microbial solubilization.PloS one · 2025Article
- Deciphering the role of recurrent FAD-dependent enzymes in bacterial phosphonate catabolism.iScience · 2023Article
- Global and seasonal variation of marine phosphonate metabolism.The ISME journal · 2022Article
- An inventory of early branch points in microbial phosphonate biosynthesis.Microbial genomics · 2022Article
- Transporter characterisation reveals aminoethylphosphonate mineralisation as a key step in the marine phosphorus redox cycle.Nature communications · 2021Article
- Discovery of a New, Recurrent Enzyme in Bacterial Phosphonate Degradation: (Biochemistry · 2021Article
- A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.Biochemistry · 2019Article
- Comparative assessment of strategies to identify similar ligand-binding pockets in proteins.BMC bioinformatics · 2018Article
- Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring.ACS synthetic biology · 2017Article
- Isolation and Characterization of Bacteria That Degrade Phosphonates in Marine Dissolved Organic Matter.Frontiers in microbiology · 2017Article
- AFrontiers in cellular and infection microbiology · 2017Article
- Biosynthesis of fosfazinomycin is a convergent process.Chemical science · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Phosphonates (C-PO₃²⁻) have applications as antibiotics, herbicides, and detergents. In some environments, these molecules represent the predominant source of phosphorus, and several microbes have evolved dedicated enzymatic machineries for phosphonate degradation. For example, most common naturally occurring phosphonates can be catabolized to either phosphonoacetaldehyde or phosphonoacetate, which can then be hydrolyzed to generate inorganic phosphate and acetaldehyde or acetate, respectively. The phosphonoacetaldehyde oxidase gene (phnY) links these two hydrolytic processes and provides a previously unknown catabolic mechanism for phosphonoacetate production in the microbial metabolome. Here, we present biochemical characterization of PhnY and high-resolution crystal structures of the apo state, as well as complexes with substrate, cofactor, and product. Kinetic analysis of active site mutants demonstrates how a highly conserved aldehyde dehydrogenase active site has been modified in nature to generate activity with a phosphonate substrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.