Evidence map›Paper›PMID 24360887›Full record

ArticleJournal of vascular and interventional radiology : JVIR2014

Pilot study of angiogenic response to yttrium-90 radioembolization with resin microspheres.

Darren R Carpizo, Rebekah H Gensure, Xin Yu, Vyacheslav M Gendel, Samuel J Greene, Dirk F Moore, Salma K Jabbour, John L Nosher

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00994370 (Measurement of Pro-angiogenic Markers in Patients With Hepatic Metastases Undergoing Selective Internal Radiation Therapy), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00994370 completednot on this map

Measurement of Pro-angiogenic Markers in Patients With Hepatic Metastases Undergoing Selective Internal Radiation Therapy (SIRT)

TypeobservationalSponsorRutgers, The State University of New JerseyRan2009 to 2013Enrolled36ConditionsLiver Cancer
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

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  14. Ytrrium-90 transarterial radioembolization in patients with gastrointestinal malignancies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Darren R CarpizoDivision of Surgical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Biomedical and Health Sciences, New Brunswick, NJ 08903-0019.
Rebekah H GensureCenter for Biomedical Imaging & Informatics, Rutgers Cancer Institute of New Jersey, Rutgers Biomedical and Health Sciences, New Brunswick, NJ 08903-0019.
Xin YuDivision of Surgical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Biomedical and Health Sciences, New Brunswick, NJ 08903-0019.
Vyacheslav M GendelDepartment of Radiology, Rutgers Robert Wood Johnson Medical School, One Robert Wood Johnson Place MEB 404, PO Box 19, New Brunswick, NJ 08903-0019.
Samuel J GreeneDepartment of Radiology, Rutgers Robert Wood Johnson Medical School, One Robert Wood Johnson Place MEB 404, PO Box 19, New Brunswick, NJ 08903-0019.
Dirk F MooreDepartment of Biostatistics, School of Public Health, Rutgers Biomedical and Health Sciences, New Brunswick, NJ 08903-0019.
Salma K JabbourDepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Biomedical and Health Sciences, New Brunswick, NJ 08903-0019.
John L NosherDepartment of Radiology, Rutgers Robert Wood Johnson Medical School, One Robert Wood Johnson Place MEB 404, PO Box 19, New Brunswick, NJ 08903-0019. Electronic address: nosher@umdnj.edu.
Johnson University · USRutgers, The State University of New Jersey · USRutgers Health

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Shridar Ganesan · 1997 to 2026
$94.5M
NCI NIH HHS P30 CA072720
6 · The paper itself

Abstract

purposeTo investigate the impact of radioembolization with yttrium-90 resin microspheres on the regulation of angiogenesis through observation of serial changes in a spectrum of angiogenic markers and other cytokines after therapy. MATERIALS AND

methodsThis prospective pilot study enrolled 22 patients with liver-dominant disease deriving from biopsy-proven hepatocellular carcinoma (HCC) (n = 7) or metastatic colorectal carcinoma (mCRC) (n = 15). Circulating angiogenic markers were measured from serum samples drawn at baseline and at time points after therapy ranging from 6 hours to 120 days. Using multiplex enzyme-linked immunosorbent assay, several classic angiogenesis factors (vascular endothelial growth factor [VEGF], angiopoietin-2 [Ang-2], basic fibroblast growth factor [bFGF], platelet-derived growth factor subunit BB [PDGF-BB], thrombospondin-1 [Tsp-1]) and nonclassic factors (follistatin, leptin, interleukin [IL]-8) were evaluated.

resultsIncreases in cytokine levels ≥ 50% over baseline were observed in more than half of all patients studied for many cytokines, including classic angiogenic factors such as VEGF, Ang-2, and Tsp-1 as well as nonclassic factors IL-8 and follistatin (range, 36%-82% for all cytokines). Baseline cytokine levels in patients with overall survival (OS) < 6 months differed significantly from patients with longer survival for Ang-2 (P = .033) and IL-8 (P = .041). Patients with OS ≤ 6 months exhibited transient increases in VEGF and PDGF-BB after therapy compared with patients with OS > 6 months.

conclusionsRadioembolization is associated with early transient increases in many angiogenic cytokines. In this small sample size, some of these changes were associated with worse OS. This research has important implications for future studies of radioembolization with antiangiogenic therapy performed during and after the procedure.

Indexed as

Neovascularization, PathologicAdultAgedAged, 80 and overAngiogenic ProteinsBiomarkers, TumorCarcinomaCarcinoma, HepatocellularColorectal NeoplasmsCytokinesEmbolization, TherapeuticEnzyme-Linked Immunosorbent AssayFemaleHumansLiver NeoplasmsMaleAngiogenic ProteinsBiomarkers, TumorCytokinesRadiopharmaceuticalsResins, SyntheticYttrium Radioisotopes(90)Yacidic fibroblast growth factoraFGFAng-2angiopoietin-2basic fibroblast growth factorbFGFConcconcentrationFGFRfibroblast growth factor receptorG-CSFGM-CSFgranulocyte colony-stimulating factorgranulocyte-macrophage colony-stimulating factorHCChepatocellular carcinomahepatocyte growth factorHGFIFNILinterferoninterferon-inducible proteininterleukinIPmacrophage chemotactic and activating factormacrophage inflammatory proteinMCAFmCRCmetastatic colorectal carcinomaMIPOSoverall survivalPDGFPDGF-BBPDGFRPECAM-1platelet-derived growth factorplatelet-derived growth factor receptorplatelet-derived growth factor subunit BBplatelet endothelial cell adhesion moleculeRANTESregulated on activation, normal T-cell expressed and secretedthrombospondin 1TNFtreatmentTsp-1tumor necrosis factorTxvascular endothelial growth factorvascular endothelial growth factor receptorVEGFVEGFRyttrium-90

Identifiers

PMID24360887
PMCPMC5496007
OpenAlexW1995338286

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.