ReviewJournal of magnetic resonance (San Diego, Calif. : 1997)2014
Homonuclear decoupling for enhancing resolution and sensitivity in NOE and RDC measurements of peptides and proteins.
Review in Journal of magnetic resonance (San Diego, Calif. : 1997), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 123 citations in OpenAlex.
- Deep Learning Assisted Proton Pure Shift NMR Spectroscopy.Journal of the American Chemical Society · 2026Article
- Enhancing both the Intensities and Resolution ofAnalytical chemistry · 2026Article
- Ultrahigh-resolution solid-state NMR for high-molecular weight proteins on GHz-class spectrometers.Science advances · 2025Article
- Neural net analysis of NMR spectra from strongly-coupled spin systems.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024Article
- Universally Quantitative Band-Selective Pure Shift NMR Spectroscopy.Analytical chemistry · 2024Article
- Conformation Analysis and Stereodynamics of SymmetricallyMolecules (Basel, Switzerland) · 2024Article
- Solvent Suppression in Pure Shift NMR.Analytical chemistry · 2024Article
- Simultaneous Broadband Suppression of Homonuclear and Heteronuclear Couplings inChemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Pure shift amide detection in conventional and TROSY-type experiments ofJournal of biomolecular NMR · 2022Article
- Boosting the resolution of multidimensional NMR spectra by complete removal of proton spin multiplicities.Scientific reports · 2021Article
- Detecting anisotropic segmental dynamics in disordered proteins by cross-correlated spin relaxation.Magnetic resonance (Gottingen, Germany) · 2021Article
- Dispersion from CJournal of biomolecular NMR · 2020Article
- CSSF-CLIP-HSQMBC: measurement of heteronuclear coupling constants in severely crowded spectral regions.RSC advances · 2019Article
- Practical aspects of real-time pure shift HSQC experiments.Magnetic resonance in chemistry : MRC · 2018Article
- The GNAT: A new tool for processing NMR data.Magnetic resonance in chemistry : MRC · 2018Article
- Perfecting band selective homo-decoupling for decoupling two signals coupled within the same band.RSC advances · 2018Article
- SHARPER Reaction Monitoring: Generation of a Narrow Linewidth NMR Singlet, without X-Pulses, in an Inhomogeneous Magnetic Field.Analytical chemistry · 2017Article
- Quarterly intrinsic disorder digest (April-May-June, 2014).Intrinsically disordered proteins · 2017Article
- Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains.Biochemistry · 2016Article
- Quantitative evaluation of positive ϕ angle propensity in flexible regions of proteins from three-bond J couplings.Physical chemistry chemical physics : PCCP · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Application of band-selective homonuclear (BASH) (1)H decoupling pulses during acquisition of the (1)H free induction decay is shown to be an efficient procedure for removal of scalar and residual dipolar couplings between amide and aliphatic protons. BASH decoupling can be applied in both dimensions of a homonuclear 2D NMR experiment and is particularly useful for enhancing spectral resolution in the H(N)-H(α) region of NOESY spectra of peptides and proteins, which contain important information on the backbone torsion angles. The method then also prevents generation of zero quantum and Hz(N)-Hz(α) terms, thereby facilitating analysis of intraresidue interactions. Application to the NOESY spectrum of a hexapeptide fragment of the intrinsically disordered protein α-synuclein highlights the considerable diffusion anisotropy present in linear peptides. Removal of residual dipolar couplings between H(N) and aliphatic protons in weakly aligned proteins increases resolution in the (1)H-(15)N HSQC region of the spectrum and allows measurement of RDCs in samples that are relatively strongly aligned. The approach is demonstrated for measurement of RDCs in protonated (15)N/(13)C-enriched ubiquitin, aligned in Pf1, yielding improved fitting to the ubiquitin structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.