ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2014
Cardiometabolic risk in overweight subjects with or without relative fat-free mass deficiency: the Strong Heart Study.
Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- A comparison of principal component analysis, reduced-rank regression, and partial least-squares in the identification of dietary patterns associated with cardiometabolic risk factors in Iranian overweight and obese women.BMC medical research methodology · 2024Article
- Obesity: the perfect storm for heart failure.ESC heart failure · 2024Review
- A New Approach Using BMI and FMI as Predictors of Cardio-Vascular Risk Factors among Mexican Young Adults.European journal of investigation in health, psychology and education · 2023Article
- Carotid Atherosclerosis Predicts Blood Pressure Control in Patients With Hypertension: The Campania Salute Network Registry.Journal of the American Heart Association · 2022Article
- Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: a gender-stratified 15.5-year follow-up.BMC public health · 2021Article
- Relationship between arm-to-leg and limbs-to-trunk body composition ratio and cardiovascular disease risk factors.Scientific reports · 2021Article
- Assessment of carotid cross-sectional area in hypertensive patients: phenotyping and prognostic validation in The Campania Salute Network.Journal of human hypertension · 2021Article
- Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity.International journal of obesity (2005) · 2020Article
- Sex differences in cardiometabolic disorders.Nature medicine · 2019Review
- Inappropriate Left Ventricular Mass and Cardiovascular Disease Events and Mortality in Blacks: The Jackson Heart Study.Journal of the American Heart Association · 2019Article
- Depressed Myocardial Energetic Efficiency Increases Risk of Incident Heart Failure: The Strong Heart Study.Journal of clinical medicine · 2019Article
- Myocardial mechano-energetic efficiency and insulin resistance in non-diabetic members of the Strong Heart Study cohort.Cardiovascular diabetology · 2019Article
- Target organ damage and incident type 2 diabetes mellitus: the Strong Heart Study.Cardiovascular diabetology · 2017Article
- Consumption of a high-fat breakfast on consecutive days alters preclinical biomarkers for atherosclerosis.European journal of clinical nutrition · 2017Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimSarcopenia is a condition mainly due to loss of fat-free mass (FFM) in elderly individuals. RFFMD, however, is also frequent in obese subjects due to abnormal body composition. Objective of this study was to evaluate the impact of relative fat-free mass deficiency (RFFMD) on cardiometabolic (CM) risk in obese normoglycemic individuals. METHODS AND
resultsOverweight/obese American Indians from the Strong Heart Study population, without diabetes and with FBG ≤ 110 mg/dL and with GFR >60 mg/mL/1.73 m(2) were selected for this analysis (n = 742). RFFMD was defined on the basis of a multivariable equation previously reported. Fasting glucose and 2 h-OGTT were measured together with urine albumin/creatinine excretion, laboratory and anthropometric parameters. In addition to lower FFM and greater adipose mass, participants with RFFMD had higher body mass index, waist circumference, C-reactive protein, fibrinogen, insulin resistance and urinary albumin/creatinine than participants with normal FFM (all p < 0.001); they also had a greater prevalence of hypertension, impaired glucose tolerance (IGT) or OGTT-diabetes than participants with normal FFM (all p < 0.003) and a near 2-fold greater probability of significant proteinuria (p < 0.01). RFFMD was more frequent in women than in men: significant sex-RFFMD interactions were found for BMI and waist circumference (both p < 0.0001).
conclusionsRFFMD in overweight/obese normoglycemic individuals is associated with greater probability of hypertension, abnormalities of glucose tolerance and proteinuria. Assessment of RFFRMD might, therefore, help stratifying cardiometabolic risk among normoglycemic individuals with overweight/obesity.
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