ArticleCell2013
A bidirectional circuit switch reroutes pheromone signals in male and female brains.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
98 citing papers in PubMed, 203 citations in OpenAlex.
- Convergent olfactory circuits for courtship in Drosophila revealed by the circuit-tracing tool ds-Tango.Current biology : CB · 2026Article
- Fruitless produces diverse neuronal sex differences by editing lineage-programmed chromatin landscapes.bioRxiv : the preprint server for biology · 2026Article
- Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.Nature communications · 2026Article
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- Divergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit.Current biology : CB · 2025Article
- Hierarchical diversification of instinctual behavior neurons by lineage, birth order, and sex.bioRxiv : the preprint server for biology · 2025Article
- The role ofScience advances · 2024Article
- The synaptic basis for sexual dimorphism in the invertebrate nervous system.Current opinion in neurobiology · 2023Review
- A Neural Circuit Controlling Virgin Female Aggression Induced by Mating-related Cues in Drosophila.Neuroscience bulletin · 2023Article
- Olfactory navigation in arthropods.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Article
- GABA-mediated inhibition in visual feedback neurons fine-tunesbioRxiv : the preprint server for biology · 2023Article
- Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot.Frontiers in molecular neuroscience · 2023Review
- Review
- Rapid reconstruction of neural circuits using tissue expansion and light sheet microscopy.eLife · 2022Article
- Olfactory responses ofeLife · 2022Article
- A dopamine-gated learning circuit underpins reproductive state-dependent odor preference ineLife · 2022Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Connectomic features underlying diverse synaptic connection strengths and subcellular computation.Current biology : CB · 2022Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila sex pheromone cVA elicits different behaviors in males and females. First- and second-order olfactory neurons show identical pheromone responses, suggesting that sex genes differentially wire circuits deeper in the brain. Using in vivo whole-cell electrophysiology, we now show that two clusters of third-order olfactory neurons have dimorphic pheromone responses. One cluster responds in females; the other responds in males. These clusters are present in both sexes and share a common input pathway, but sex-specific wiring reroutes pheromone information. Regulating dendritic position, the fruitless transcription factor both connects the male-responsive cluster and disconnects the female-responsive cluster from pheromone input. Selective masculinization of third-order neurons transforms their morphology and pheromone responses, demonstrating that circuits can be functionally rewired by the cell-autonomous action of a switch gene. This bidirectional switch, analogous to an electrical changeover switch, provides a simple circuit logic to activate different behaviors in males and females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.