Evidence map›Paper›PMID 24360270›Full record

ArticleCell2013

Probing DNA by 2-OG-dependent dioxygenase.

Chi-Lin Tsai, John A Tainer

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Structure and Function of TET Enzymes.Advances in experimental medicine and biology · 2022
    Article
  3. Review
  4. Comparison of DNA and RNA substrate effects on TET2 structure.Advances in protein chemistry and structural biology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Chi-Lin TsaiLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
John A TainerLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: jat@scripps.edu.
Lawrence Berkeley National Laboratory · USScripps Research Institute · US

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
STRUCTURE AND FUNCTION OF METALLOENZYMES FOR DNA REPAIRR01GM046312 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI TAINER, JOHN A. · 1991 to 2012
$5.9M
Structural Biochemistry of DNA DealkylationR01CA097209 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI TAINER, JOHN A. · 2002 to 2014
$4.4M
NCI NIH HHS P01 CA092584NCI NIH HHS R01 CA097209NIGMS NIH HHS R01 GM046312
6 · The paper itself

Abstract

TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.

Indexed as

5-MethylcytosineDioxygenasesDNADNA-Binding ProteinsHumansProto-Oncogene Proteins5-MethylcytosineDioxygenasesDNADNA-Binding ProteinsProto-Oncogene ProteinsTET2 protein, human

Identifiers

PMID24360270
PMCPMC3916139
OpenAlexW2040582568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.