ArticleJournal of biomechanics2014
Multiscale analysis of morphology and mechanics in tail tendon from the ZDSD rat model of type 2 diabetes.
Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Serum Advanced Glycation End Products as Drivers of Poor Tendon Outcomes in Diabetes? An Emerging Hypothesis and Narrative Review.Endocrinology, diabetes & metabolism · 2026Review
- The Impact of Ageing on Fibrillar Collagens.Sub-cellular biochemistry · 2026Review
- Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes.Frontiers in physiology · 2025Article
- Type 2 diabetes alters the viscoelastic behavior and macromolecular composition of vertebra.Bone reports · 2023Article
- Quercetin treatment protects the Achilles tendons of rats from oxidative stress induced by hyperglycemia.BMC musculoskeletal disorders · 2022Article
- Influence of Diabetes-Induced Glycation and Oxidative Stress on the Human Rotator Cuff.Antioxidants (Basel, Switzerland) · 2022Article
- Zucker Diabetic-Sprague Dawley (ZDSD) rat: Type 2 diabetes translational research model.Experimental physiology · 2022Review
- Human Achilles tendon mechanical behavior is more strongly related to collagen disorganization than advanced glycation end-products content.Scientific reports · 2021Article
- Understanding cellular and molecular mechanisms of pathogenesis of diabetic tendinopathy.World journal of stem cells · 2020Review
- Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- The Nile Rat (Arvicanthis niloticus) as a Superior Carbohydrate-Sensitive Model for Type 2 Diabetes Mellitus (T2DM).Nutrients · 2018Review
- Experimental Diabetes Alters the Morphology and Nano-Structure of the Achilles Tendon.PloS one · 2017Article
- Article
- Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes.Journal of diabetes research · 2015Article
- Exercise prevents β-aminopropionitrile-induced morphological changes to type I collagen in murine bone.BoneKEy reports · 2015Article
- Diabetes alters mechanical properties and collagen fiber re-alignment in multiple mouse tendons.Annals of biomedical engineering · 2014Article
- A review of rodent models of type 2 diabetic skeletal fragility.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Type 2 diabetes (T2D) impacts multiple organ systems including the circulatory, renal, nervous and musculoskeletal systems. In collagen-based tissues, one mechanism that may be responsible for detrimental mechanical impacts of T2D is the formation of advanced glycation end products (AGEs) leading to increased collagen stiffness and decreased toughness, resulting in brittle tissue behavior. The purpose of this study was to investigate tendon mechanical properties from normal and diabetic rats at two distinct length scales, testing the hypothesis that increased stiffness and strength and decreased toughness at the fiber level would be associated with alterations in nanoscale morphology and mechanics. Individual fascicles from female Zucker diabetic Sprague-Dawley (ZDSD) rats had no differences in fascicle-level mechanical properties but had increased material-level strength and stiffness versus control rats (CD). At the nanoscale, collagen fibril D-spacing was shifted towards higher spacing values in diabetic ZDSD fibrils. The distribution of nanoscale modulus values was also shifted to higher values. Material-level strength and stiffness from whole fiber tests were increased in ZDSD tails. Correlations between nanoscale and microscale properties indicate a direct positive relationship between the two length scales, most notably in the relationship between nanoscale and microscale modulus. These findings indicate that diabetes-induced changes in material strength and modulus were driven by alterations at the nanoscale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.