Evidence map›Paper›PMID 24359877›Full record

SynthesisJournal of psychiatry & neuroscience : JPN2014

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people with substance dependence and behavioural addictions.

Maartje Luijten, Marise W J Machielsen, Dick J Veltman, Robert Hester, Lieuwe de Haan, Ingmar H A Franken

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03220776 (Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics), which is not on this map. Cited by 186 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 9 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03220776 phase2completednot on this mapstarted 2017, after this paper: background citation

Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics

TypeinterventionalSponsorMedical University of South CarolinaRan2017 to 2022Enrolled54ConditionsAlcohol Use Disorder, Bipolar DisorderArmsN-Acetylcysteine, Gabapentin, Placebo Oral Tablet
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 9 syntheses or guidelines pooled it, 356 citations in OpenAlex.

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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Maartje LuijtenInstitute of Psychology, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Marise W J MachielsenAcademic Medical Center, University of Amsterdam, Department of Psychiatry, Early Psychosis Department, Amsterdam, the Netherlands.
Dick J VeltmanAcademic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam, the Netherlands.
Robert HesterSchool of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Lieuwe de HaanAcademic Medical Center, University of Amsterdam, Department of Psychiatry, Early Psychosis Department, Amsterdam, the Netherlands.
Ingmar H A FrankenInstitute of Psychology, Erasmus University Rotterdam, Rotterdam, the Netherlands.
University of Melbourne · AUAcademic Medical Center · NLAmsterdam Institute for Addiction Research · NLErasmus University Rotterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral current theories emphasize the role of cognitive control in addiction. The present review evaluates neural deficits in the domains of inhibitory control and error processing in individuals with substance dependence and in those showing excessive addiction-like behaviours. The combined evaluation of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) findings in the present review offers unique information on neural deficits in addicted individuals.

methodsWe selected 19 ERP and 22 fMRI studies using stop-signal, go/no-go or Flanker paradigms based on a search of PubMed and Embase.

resultsThe most consistent findings in addicted individuals relative to healthy controls were lower N2, error-related negativity and error positivity amplitudes as well as hypoactivation in the anterior cingulate cortex (ACC), inferior frontal gyrus and dorsolateral prefrontal cortex. These neural deficits, however, were not always associated with impaired task performance. With regard to behavioural addictions, some evidence has been found for similar neural deficits; however, studies are scarce and results are not yet conclusive. Differences among the major classes of substances of abuse were identified and involve stronger neural responses to errors in individuals with alcohol dependence versus weaker neural responses to errors in other substance-dependent populations. LIMITATIONS: Task design and analysis techniques vary across studies, thereby reducing comparability among studies and the potential of clinical use of these measures.

conclusionCurrent addiction theories were supported by identifying consistent abnormalities in prefrontal brain function in individuals with addiction. An integrative model is proposed, suggesting that neural deficits in the dorsal ACC may constitute a hallmark neurocognitive deficit under lying addictive behaviours, such as loss of control.

Indexed as

Inhibition, PsychologicalBehavior, AddictiveBrainEvoked PotentialsExecutive FunctionHumansMagnetic Resonance ImagingModels, NeurologicalPsychomotor PerformanceSubstance-Related Disorders

Identifiers

PMID24359877
PMCPMC3997601
OpenAlexW1602290488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.